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Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy

Natalia Nikolaevna Sudareva 1, 2
Natalia Nikolaevna Sudareva
,  , 
Dmitry N Suslov 3
Dmitry N Suslov
,  , 
Konstantin Andreevich Kolbe 1
Konstantin Andreevich Kolbe
, 
Galina Yur'evna Yukina 2
Galina Yur'evna Yukina
, 
Margarita Leonidovna Tyndyk 3
Margarita Leonidovna Tyndyk
, 
Yulia G. Zmitrichenko 3
Yulia G. Zmitrichenko
, 
Evgenia Georgievna Korzhikova-Vlakh 1, 4
Evgenia Georgievna Korzhikova-Vlakh
1 Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russian Federation
2 I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
3 N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Russian Federation
4 Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
10.1016/j.mencom.2024.01.006
Published 2023-12-25
Communication , Volume 34, Issue 1, 18-21
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Sudareva N. N. et al. Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 18-21.
GOST all authors (up to 50) Copy
Sudareva N. N., Tarasenko I. I., Suslov D. N., Suvorova O. M., Kolbe K. A., Yukina G. Y., Tyndyk M. L., Zmitrichenko Y. G., Korzhikova-Vlakh E. G. Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy // Mendeleev Communications. 2023. Vol. 34. No. 1. pp. 18-21.
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TY - JOUR
DO - 10.1016/j.mencom.2024.01.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.006
TI - Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy
T2 - Mendeleev Communications
AU - Sudareva, Natalia Nikolaevna
AU - Tarasenko, Irina Il'inichna
AU - Suslov, Dmitry N
AU - Suvorova, Olga Mikhaylovna
AU - Kolbe, Konstantin Andreevich
AU - Yukina, Galina Yur'evna
AU - Tyndyk, Margarita Leonidovna
AU - Zmitrichenko, Yulia G.
AU - Korzhikova-Vlakh, Evgenia Georgievna
PY - 2023
DA - 2023/12/25
PB - Mendeleev Communications
SP - 18-21
IS - 1
VL - 34
ER -
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@article{2023_Sudareva,
author = {Natalia Nikolaevna Sudareva and Irina Il'inichna Tarasenko and Dmitry N Suslov and Olga Mikhaylovna Suvorova and Konstantin Andreevich Kolbe and Galina Yur'evna Yukina and Margarita Leonidovna Tyndyk and Yulia G. Zmitrichenko and Evgenia Georgievna Korzhikova-Vlakh},
title = {Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy},
journal = {Mendeleev Communications},
year = {2023},
volume = {34},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.006},
number = {1},
pages = {18--21},
doi = {10.1016/j.mencom.2024.01.006}
}
MLA
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MLA Copy
Sudareva, Natalia Nikolaevna, et al. “Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy.” Mendeleev Communications, vol. 34, no. 1, Dec. 2023, pp. 18-21. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2024.01.006.
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Keywords

cancer treatment
delivery systems
doxorubicin
nanoparticles
subcutaneous administration.
synthetic polypeptides

Abstract

Polypeptide-based doxorubicin delivery systems were prepared and their physicochemical and functional properties, such as size, encapsulation efficiency, stability, release of doxorubicin in various media and cytotoxicity, were characterized. An in vivo study revealed an effective reduction of tumor growth when these systems were administered subcutaneously.

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