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Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity

Olga Vladislavovna Mikolaichuk 1, 2
Olga Vladislavovna Mikolaichuk
, 
Olga Sergeevna Shemchuk 1, 3
Olga Sergeevna Shemchuk
, 
Alexandra Vladimirovna Protas 1, 2
Alexandra Vladimirovna Protas
, 
Elena Aleksandrovna Popova 1, 2
Elena Aleksandrovna Popova
, 
Vladimir Aronovich Ostrovskii 4
Vladimir Aronovich Ostrovskii
, 
Dmitrii Nikolaevich Maistrenko 2
Dmitrii Nikolaevich Maistrenko
, 
Oleg Evgen'evich Molchanov 2
Oleg Evgen'evich Molchanov
, 
Vladimir Vladimirovich Sharoyko 1, 2, 3
Vladimir Vladimirovich Sharoyko
, 
Konstantin Nikolaevich Semenov 1, 2, 3
Konstantin Nikolaevich Semenov
1 I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
2 A.M. Granov Russian Research Center for Radiology and Surgical Technologies, St. Petersburg, Russian Federation
3 Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
4 St. Petersburg State Institute of Technology (Technical University), St. Petersburg, Russian Federation
10.1016/j.mencom.2023.10.017
Published 2023-10-18
Communication , Volume 33, Issue 6, 790-792
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Mikolaichuk O. V. et al. Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 790-792.
GOST all authors (up to 50) Copy
Mikolaichuk O. V., Shemchuk O. S., Protas A. V., Popova E. A., Ostrovskii V. A., Maistrenko D. N., Molchanov O. E., Sharoyko V. V., Semenov K. N. Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 790-792.
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TY - JOUR
DO - 10.1016/j.mencom.2023.10.017
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.017
TI - Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity
T2 - Mendeleev Communications
AU - Mikolaichuk, Olga Vladislavovna
AU - Shemchuk, Olga Sergeevna
AU - Protas, Alexandra Vladimirovna
AU - Popova, Elena Aleksandrovna
AU - Ostrovskii, Vladimir Aronovich
AU - Maistrenko, Dmitrii Nikolaevich
AU - Molchanov, Oleg Evgen'evich
AU - Sharoyko, Vladimir Vladimirovich
AU - Semenov, Konstantin Nikolaevich
PY - 2023
DA - 2023/10/18
PB - Mendeleev Communications
SP - 790-792
IS - 6
VL - 33
ER -
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@article{2023_Mikolaichuk,
author = {Olga Vladislavovna Mikolaichuk and Olga Sergeevna Shemchuk and Alexandra Vladimirovna Protas and Elena Aleksandrovna Popova and Vladimir Aronovich Ostrovskii and Dmitrii Nikolaevich Maistrenko and Oleg Evgen'evich Molchanov and Vladimir Vladimirovich Sharoyko and Konstantin Nikolaevich Semenov},
title = {Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.017},
number = {6},
pages = {790--792},
doi = {10.1016/j.mencom.2023.10.017}
}
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Mikolaichuk, Olga Vladislavovna, et al. “Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity.” Mendeleev Communications, vol. 33, no. 6, Oct. 2023, pp. 790-792. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.017.

Keywords

1
3
5-triazine
cytotoxicity.
graphene oxide
hemolysis
tetrazole

Abstract

The synthesis, identification and evaluation of the biological activity of a new non-covalent conjugate based on graphene oxide and (5-{[4,6-di(aziridin-1-yl)-1,3,5-triazin-2-yl]-amino}-2,2-dimethyl-1,3-dioxan-5-yl)methyl (5-phenyl-2H-tetrazol-2-yl)acetate were carried out. It was shown that the synthesized nanoconjugate is hemocompatible over the entire studied concentration range (10-100 μm) and demonstrates antiradical activity under irradiation. In addition, the conjugate exhibits cytotoxicity against A549 and HeLa cell lines with IC50 values of 4.0 and 73.7 μm, respectively.

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