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Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects

Aleksey Valer'evich Tarasiuk 1
Aleksey Valer'evich Tarasiuk
, 
Nellya Mikhailovna Sazonova 1
Nellya Mikhailovna Sazonova
, 
Marina Valer'evna Melnikova 1
Marina Valer'evna Melnikova
, 
Sergey V Pomogaybo 1
Sergey V Pomogaybo
, 
Ilya Olegovich Logvinov 1
Ilya Olegovich Logvinov
, 
Sergey Vladimirovich Nikolaev 1
Sergey Vladimirovich Nikolaev
, 
Dmtriy Mikhaylovich Nikiforov 1
Dmtriy Mikhaylovich Nikiforov
, 
Tatiana Alekseevna Antipova 1
Tatiana Alekseevna Antipova
, 
Polina Yur'evna Povarnina 1
Polina Yur'evna Povarnina
, 
Yulia Venerovna Vakhitova 1
Yulia Venerovna Vakhitova
, 
Tatiana Alexandrovna Gudasheva 1
Tatiana Alexandrovna Gudasheva
, 
Sergey Borisovich Seredenin 1
Sergey Borisovich Seredenin
1 V.V. Zakusov Research Institute of Pharmacology, Moscow, Russian Federation
10.1016/j.mencom.2023.10.016
Published 2023-10-18
Communication , Volume 33, Issue 6, 786-789
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Tarasiuk A. V. et al. Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 786-789.
GOST all authors (up to 50) Copy
Tarasiuk A. V., Sazonova N. M., Melnikova M. V., Pomogaybo S. V., Logvinov I. O., Nikolaev S. V., Nikiforov D. M., Antipova T. A., Povarnina P. Y., Vakhitova Y. V., Gudasheva T. A., Seredenin S. B. Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 786-789.
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TY - JOUR
DO - 10.1016/j.mencom.2023.10.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.016
TI - Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects
T2 - Mendeleev Communications
AU - Tarasiuk, Aleksey Valer'evich
AU - Sazonova, Nellya Mikhailovna
AU - Melnikova, Marina Valer'evna
AU - Pomogaybo, Sergey V
AU - Logvinov, Ilya Olegovich
AU - Nikolaev, Sergey Vladimirovich
AU - Nikiforov, Dmtriy Mikhaylovich
AU - Antipova, Tatiana Alekseevna
AU - Povarnina, Polina Yur'evna
AU - Vakhitova, Yulia Venerovna
AU - Gudasheva, Tatiana Alexandrovna
AU - Seredenin, Sergey Borisovich
PY - 2023
DA - 2023/10/18
PB - Mendeleev Communications
SP - 786-789
IS - 6
VL - 33
ER -
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@article{2023_Tarasiuk,
author = {Aleksey Valer'evich Tarasiuk and Nellya Mikhailovna Sazonova and Marina Valer'evna Melnikova and Sergey V Pomogaybo and Ilya Olegovich Logvinov and Sergey Vladimirovich Nikolaev and Dmtriy Mikhaylovich Nikiforov and Tatiana Alekseevna Antipova and Polina Yur'evna Povarnina and Yulia Venerovna Vakhitova and Tatiana Alexandrovna Gudasheva and Sergey Borisovich Seredenin},
title = {Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Oct},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.016},
number = {6},
pages = {786--789},
doi = {10.1016/j.mencom.2023.10.016}
}
MLA
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Tarasiuk, Aleksey Valer'evich, et al. “Design and synthesis of a novel dipeptide mimetic of the 4th loop of neurotrophin-3 and its pharmacological effects.” Mendeleev Communications, vol. 33, no. 6, Oct. 2023, pp. 786-789. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.10.016.

Keywords

antidepressant-like activity.
cytoprotective activity
design
dipeptide mimetic
low-molecular mimetic
neurotrophin-3

Abstract

A novel neurotrophin-3 loop 4 dipeptide mimetic, bis(N-γ-hydroxybutyryl-L-glutamyl-L-asparagine) hexamethylenedi-amide (GTS-302), was designed and synthesized. Compound GTS-302 activated the tyrosine kinase receptors TrkC and TrkB, exhibited cytoprotective activity (10-8-10-5 M) in oxidative stress model in HT-22 cells and in 6-hydroxy-dopamine-induced SH-SY5Y cell damage. It also demon- strated an antidepressant-like activity in the forced swim test in mice (0.5-10.0 mg kg-1, intraperitoneally).

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