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Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods

Julia Olegovna Kotova 1
Julia Olegovna Kotova
, 
Nadezhda Sergeevna Osipova 1
Nadezhda Sergeevna Osipova
, 
Julia Aleksandrovna Malinovskaya 1, 2
Julia Aleksandrovna Malinovskaya
, 
Pavel A Melnikov 2
Pavel A Melnikov
, 
Svetlana Emmanuilovna Gelperina 1
Svetlana Emmanuilovna Gelperina
1 D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
2 V.P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Moscow, Russian Federation
10.1016/j.mencom.2023.09.027
Published 2023-09-01
Communication , Volume 33, Issue 5, 676-678
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Kotova J. O. et al. Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 676-678.
GOST all authors (up to 50) Copy
Kotova J. O., Osipova N. S., Malinovskaya J. A., Melnikov P. A., Gelperina S. E. Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 676-678.
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TY - JOUR
DO - 10.1016/j.mencom.2023.09.027
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.027
TI - Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods
T2 - Mendeleev Communications
AU - Kotova, Julia Olegovna
AU - Osipova, Nadezhda Sergeevna
AU - Malinovskaya, Julia Aleksandrovna
AU - Melnikov, Pavel A
AU - Gelperina, Svetlana Emmanuilovna
PY - 2023
DA - 2023/09/01
PB - Mendeleev Communications
SP - 676-678
IS - 5
VL - 33
ER -
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@article{2023_Kotova,
author = {Julia Olegovna Kotova and Nadezhda Sergeevna Osipova and Julia Aleksandrovna Malinovskaya and Pavel A Melnikov and Svetlana Emmanuilovna Gelperina},
title = {Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.027},
number = {5},
pages = {676--678},
doi = {10.1016/j.mencom.2023.09.027}
}
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Kotova, Julia Olegovna, et al. “Properties of core-shell nanoparticles based on PLGA and human serum albumin prepared by different methods.” Mendeleev Communications, vol. 33, no. 5, Sep. 2023, pp. 676-678. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.027.

Keywords

core–shell nanoparticles
drug delivery systems
human serum albumin
intracellular internalization
laser scanning confocal microscopy
LSCM.
PLGA

Abstract

Core-shell nanoparticles with poly(lactide-co-glycolide) cores and human serum albumin shells (PLGA/HSA NPs) were prepared by three methods: by interfacial embedding of HSA in the PLGA NP surface during their formation and by adsorption or conjugation of HSA on pre-prepared PLGA NPs. All methods yielded PLGA/HSA NPs with a size of 130-150 nm and a narrow size distribution. In vitro fluorescence microscopy revealed the integrity of all core-shell systems when internalized in GL261 cells.

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