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Sortase-promoted synthesis of homooligomers from a monomeric protein

Tatiana Dmitrievna Melikhova 1
Tatiana Dmitrievna Melikhova
, 
Nicolai Vladimirovich Bovin 1
Nicolai Vladimirovich Bovin
, 
Alexandr D Antipov 1
Alexandr D Antipov
, 
Mikhail Nikolaevich Tereshin 1
Mikhail Nikolaevich Tereshin
, 
Rustam Husmanovich Ziganshin 1
Rustam Husmanovich Ziganshin
, 
Alexander Borisovich Tuzikov 1
Alexander Borisovich Tuzikov
1 M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2023.09.011
Published 2023-09-01
Communication , Volume 33, Issue 5, 624-626
2
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Melikhova T. D. et al. Sortase-promoted synthesis of homooligomers from a monomeric protein // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 624-626.
GOST all authors (up to 50) Copy
Melikhova T. D., Bovin N. V., Antipov A. D., Tereshin M. N., Ziganshin R. H., Tuzikov A. B. Sortase-promoted synthesis of homooligomers from a monomeric protein // Mendeleev Communications. 2023. Vol. 33. No. 5. pp. 624-626.
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TY - JOUR
DO - 10.1016/j.mencom.2023.09.011
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.011
TI - Sortase-promoted synthesis of homooligomers from a monomeric protein
T2 - Mendeleev Communications
AU - Melikhova, Tatiana Dmitrievna
AU - Bovin, Nicolai Vladimirovich
AU - Antipov, Alexandr D
AU - Tereshin, Mikhail Nikolaevich
AU - Ziganshin, Rustam Husmanovich
AU - Tuzikov, Alexander Borisovich
PY - 2023
DA - 2023/09/01
PB - Mendeleev Communications
SP - 624-626
IS - 5
VL - 33
ER -
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@article{2023_Melikhova,
author = {Tatiana Dmitrievna Melikhova and Nicolai Vladimirovich Bovin and Alexandr D Antipov and Mikhail Nikolaevich Tereshin and Rustam Husmanovich Ziganshin and Alexander Borisovich Tuzikov},
title = {Sortase-promoted synthesis of homooligomers from a monomeric protein},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.011},
number = {5},
pages = {624--626},
doi = {10.1016/j.mencom.2023.09.011}
}
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Melikhova, Tatiana Dmitrievna, et al. “Sortase-promoted synthesis of homooligomers from a monomeric protein.” Mendeleev Communications, vol. 33, no. 5, Sep. 2023, pp. 624-626. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.09.011.

Keywords

bioconjugation
oligoglycine
protein A
protein homooligomerization.
sortase

Abstract

We demonstrated covalent cross-linking of two or three protein molecules specifically at the C-terminus by sortase-catalyzed conjugation of recombinant proteins with conformationally rigid-flexible tetraantennary templates, where structure of the antenna is [Gly-Gly-(N-CH2COOH)Gly]nCH2-.

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