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Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity

Vasily Vladimirovich Spiridonov 1
Vasily Vladimirovich Spiridonov
, 
Alina Radikovna Lukmanova 2
Alina Radikovna Lukmanova
,  , 
Alina Alexandrovna Markova 4
Alina Alexandrovna Markova
, 
Yuliya Leonidovna Volodina 5
Yuliya Leonidovna Volodina
, 
Galina Vladimirovna Golovina 4
Galina Vladimirovna Golovina
, 
Vladimir Victorovich Shakhmatov 4
Vladimir Victorovich Shakhmatov
, 
Vladimir Alexandrovich Kuzmin 4
Vladimir Alexandrovich Kuzmin
, 
Vladimir Izrailevich Muronetz 3
Vladimir Izrailevich Muronetz
, 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Department of Materials Science, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
3 A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
4 N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
5 N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
10.1016/j.mencom.2023.06.036
Published 2023-06-13
Communication , Volume 33, Issue 4, 553-555
6
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Spiridonov V. V. et al. Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 553-555.
GOST all authors (up to 50) Copy
Spiridonov V. V., Lukmanova A. R., Pozdyshev D. V., Markova A. A., Volodina Y. L., Golovina G. V., Shakhmatov V. V., Kuzmin V. A., Muronetz V. I., Yaroslavov A. A. Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 553-555.
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TY - JOUR
DO - 10.1016/j.mencom.2023.06.036
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.036
TI - Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity
T2 - Mendeleev Communications
AU - Spiridonov, Vasily Vladimirovich
AU - Lukmanova, Alina Radikovna
AU - Pozdyshev, Denis Valerievich
AU - Markova, Alina Alexandrovna
AU - Volodina, Yuliya Leonidovna
AU - Golovina, Galina Vladimirovna
AU - Shakhmatov, Vladimir Victorovich
AU - Kuzmin, Vladimir Alexandrovich
AU - Muronetz, Vladimir Izrailevich
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2023
DA - 2023/06/13
PB - Mendeleev Communications
SP - 553-555
IS - 4
VL - 33
ER -
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@article{2023_Spiridonov,
author = {Vasily Vladimirovich Spiridonov and Alina Radikovna Lukmanova and Denis Valerievich Pozdyshev and Alina Alexandrovna Markova and Yuliya Leonidovna Volodina and Galina Vladimirovna Golovina and Vladimir Victorovich Shakhmatov and Vladimir Alexandrovich Kuzmin and Vladimir Izrailevich Muronetz and Aleksandr Anatol'evich Yaroslavov},
title = {Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.036},
number = {4},
pages = {553--555},
doi = {10.1016/j.mencom.2023.06.036}
}
MLA
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MLA Copy
Spiridonov, Vasily Vladimirovich, et al. “Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity.” Mendeleev Communications, vol. 33, no. 4, Jun. 2023, pp. 553-555. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.036.

Keywords

cross-linked hydrogels
cytotoxicity.
doxorubicin
intracell migration
rhodamine
sodium alginate

Abstract

Micro-sized hydrogels synthesized by electrostatic cross-linking of anionic alginate with Ca2+ cations were additionally loaded with cationic fluorescent dye Rhodamine 6B or cationic antitumor antibiotic doxorubicin. Forming complexes with Ca2+ alginate hydrogels, doxorubicin retained or even reduced its toxicity to tumor and normal cells. The results can be used to design containers for the encapsulation and delivery of drugs and control their interaction with cells.

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