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Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation

, 
Stanislav Alexandrovich Petrov 1
Stanislav Alexandrovich Petrov
,  , 
Anastasiya Alekseevna Uspenskaya 1
Anastasiya Alekseevna Uspenskaya
, 
Pavel Alekseevich Krasnikov 1
Pavel Alekseevich Krasnikov
, 
Natalya Sergeevna Volkova 1
Natalya Sergeevna Volkova
, 
Elena Kimovna Beloglazkina 1
Elena Kimovna Beloglazkina
, 
Alexander Georgievich Majouga 1, 2, 3
Alexander Georgievich Majouga
, 
Nikolai Vasil'evich Zyk 1
Nikolai Vasil'evich Zyk
, 
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
3 National University of Science and Technology 'MISIS', Moscow, Russian Federation
10.1016/j.mencom.2023.06.010
Published 2023-06-13
Communication , Volume 33, Issue 4, 472-475
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Zyk N. Y. et al. Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 472-475.
GOST all authors (up to 50) Copy
Zyk N. Y., Petrov S. A., Zavertkina M. V., Uspenskaya A. A., Krasnikov P. A., Volkova N. S., Beloglazkina E. K., Majouga A. G., Zyk N. V., Machulkin A. E. Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 472-475.
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TY - JOUR
DO - 10.1016/j.mencom.2023.06.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.010
TI - Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation
T2 - Mendeleev Communications
AU - Zyk, Nikolay Yurievich
AU - Petrov, Stanislav Alexandrovich
AU - Zavertkina, Maria Vasilevna
AU - Uspenskaya, Anastasiya Alekseevna
AU - Krasnikov, Pavel Alekseevich
AU - Volkova, Natalya Sergeevna
AU - Beloglazkina, Elena Kimovna
AU - Majouga, Alexander Georgievich
AU - Zyk, Nikolai Vasil'evich
AU - Machulkin, Aleksei Eduardovich
PY - 2023
DA - 2023/06/13
PB - Mendeleev Communications
SP - 472-475
IS - 4
VL - 33
ER -
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@article{2023_Zyk,
author = {Nikolay Yurievich Zyk and Stanislav Alexandrovich Petrov and Maria Vasilevna Zavertkina and Anastasiya Alekseevna Uspenskaya and Pavel Alekseevich Krasnikov and Natalya Sergeevna Volkova and Elena Kimovna Beloglazkina and Alexander Georgievich Majouga and Nikolai Vasil'evich Zyk and Aleksei Eduardovich Machulkin},
title = {Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Jun},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.010},
number = {4},
pages = {472--475},
doi = {10.1016/j.mencom.2023.06.010}
}
MLA
Cite this
MLA Copy
Zyk, Nikolay Yurievich, et al. “Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation.” Mendeleev Communications, vol. 33, no. 4, Jun. 2023, pp. 472-475. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.06.010.

Keywords

anticancer drugs.
prostate cancer
prostatic specific membrane antigen
solid-phase peptide synthesis
targeted delivery

Abstract

Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen ligands based on Glu-Urea-Lys with peptide fragments in the linker structure are compared. In the first approach, the amino acid key intermediate is attached to the 2-CTC resin by the carboxy group while in the second approach, by the amino one. The preference for each approach is dependent on the particular target molecule

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