Keywords
2-c]pyran-2
2-c]pyrans
4
5’-pyrimidine]
6-triones.
base-oxidant system
Cyclization
furo[3
morpholinium salts
N-bromosuccinimide
pyranones
pyrimidine-2
sodium acetate
spiro[furo- [3
Abstract
Spirocyclization of morpholinium 3-[(aryl)(1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-6-methyl-2-oxo-2H-pyran-4-olate by the action of sodium acetate-N-bromosuccinimide system in ethanol at room temperature results in spiro[furo[3,2-c]pyran-2,5’-pyrimidine] derivatives in 92-98% yields, the protocol allowing to avoid column chromatography purification. This new highly efficient and facile procedure is a convenient way to substituted unsymmetrical spiro scaffold containing pyrimidine-2,4,6-trione and 2,3-dihydro-4H-furo[3,2-c]pyran-4-one fragments promising for biomedical applications.
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