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Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure

Yulia Alexeevna Puchkova 1
Yulia Alexeevna Puchkova
, 
Nikita Gennad'evich Sedush 1
Nikita Gennad'evich Sedush
, 
Antonina D Ivanenko 1
Antonina D Ivanenko
, 
Valentina Georgievna Shuvatova 1
Valentina Georgievna Shuvatova
, 
Galina Aronovna Posypanova 1
Galina Aronovna Posypanova
, 
Sergei Nikolaevich Chvalun 1, 2
Sergei Nikolaevich Chvalun
1 National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
2 N.S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2023.04.033
Published 2023-04-13
Communication , Volume 33, Issue 3, 404-407
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Puchkova Y. A. et al. Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 404-407.
GOST all authors (up to 50) Copy
Puchkova Y. A., Sedush N. G., Ivanenko A. D., Shuvatova V. G., Posypanova G. A., Chvalun S. N. Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 404-407.
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TY - JOUR
DO - 10.1016/j.mencom.2023.04.033
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.033
TI - Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure
T2 - Mendeleev Communications
AU - Puchkova, Yulia Alexeevna
AU - Sedush, Nikita Gennad'evich
AU - Ivanenko, Antonina D
AU - Shuvatova, Valentina Georgievna
AU - Posypanova, Galina Aronovna
AU - Chvalun, Sergei Nikolaevich
PY - 2023
DA - 2023/04/13
PB - Mendeleev Communications
SP - 404-407
IS - 3
VL - 33
ER -
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@article{2023_Puchkova,
author = {Yulia Alexeevna Puchkova and Nikita Gennad'evich Sedush and Antonina D Ivanenko and Valentina Georgievna Shuvatova and Galina Aronovna Posypanova and Sergei Nikolaevich Chvalun},
title = {Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.033},
number = {3},
pages = {404--407},
doi = {10.1016/j.mencom.2023.04.033}
}
MLA
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MLA Copy
Puchkova, Yulia Alexeevna, et al. “Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure.” Mendeleev Communications, vol. 33, no. 3, Apr. 2023, pp. 404-407. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.033.

Keywords

block copolymers
DBU
drug delivery systems.
metal-free ring opening polymerization
nanoparticles
poly(ethylene glycol)
poly(lactide)

Abstract

Ring-opening polymerization of lactide was performed in the presence of 1,8-diazabicyclo[5.4.0]undec-5-ene as an organic catalyst and polyethylene glycol as a hydroxyl-containing macroinitiator. A series of amphiphilic poly(ethylene glycol-block-polylactide) copolymers with a low dispersity (PDI = 1.1), different stereoregularity and length of the polylactide block was obtained. Nanoparticles with a diameter of 20-25 nm were produced from selected polymers and were studied by in vitro cytotoxicity tests.

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