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Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation

Anastasia Konstantinova 1
Anastasia Konstantinova
, 
Viktor Sergeevich Stroylov 2, 3
Viktor Sergeevich Stroylov
,  , 
Matej Sova 5
Matej Sova
, 
Saboury Ali Akbar 6
Saboury Ali Akbar
, 
Vladimir Izrailevich Muronetz 4
Vladimir Izrailevich Muronetz
, 
Yulia Yur'evna Stroylova 4, 7
Yulia Yur'evna Stroylova
1 Department of Biotechnology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
3 National Research University Higher School of Economics (HSE University), Moscow, Russian Federation
4 A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
5 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
6 Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
7 Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
10.1016/j.mencom.2023.04.012
Published 2023-04-13
Communication , Volume 33, Issue 3, 334-336
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Konstantinova A. et al. Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 334-336.
GOST all authors (up to 50) Copy
Konstantinova A., Stroylov V. S., Pozdyshev D. V., Sova M., Akbar S. A., Muronetz V. I., Stroylova Y. Y. Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 334-336.
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TY - JOUR
DO - 10.1016/j.mencom.2023.04.012
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.012
TI - Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation
T2 - Mendeleev Communications
AU - Konstantinova, Anastasia
AU - Stroylov, Viktor Sergeevich
AU - Pozdyshev, Denis Valerievich
AU - Sova, Matej
AU - Akbar, Saboury Ali
AU - Muronetz, Vladimir Izrailevich
AU - Stroylova, Yulia Yur'evna
PY - 2023
DA - 2023/04/13
PB - Mendeleev Communications
SP - 334-336
IS - 3
VL - 33
ER -
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@article{2023_Konstantinova,
author = {Anastasia Konstantinova and Viktor Sergeevich Stroylov and Denis Valerievich Pozdyshev and Matej Sova and Saboury Ali Akbar and Vladimir Izrailevich Muronetz and Yulia Yur'evna Stroylova},
title = {Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.012},
number = {3},
pages = {334--336},
doi = {10.1016/j.mencom.2023.04.012}
}
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Konstantinova, Anastasia, et al. “Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation.” Mendeleev Communications, vol. 33, no. 3, Apr. 2023, pp. 334-336. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.012.

Keywords

alpha-synuclein
amyloid aggregation
cinnamides
Parkinson’s disease.
surface docking

Abstract

Four substituted cinnamides were studied as potential inhibitors of alpha-synuclein aggregation. (E)-3-[3-(Benzo[d][1,3]dioxol-5-yl)acrylamido]benzoic acid (SMB11) was shown to inhibit amyloid fibril formation of recombinant human alpha-synuclein according to Congo Red and partial proteolysis by proteinase K assays. This compound and its analog with 3-trifluoromethylphenyl substituent demonstrated no cytotoxicity on human neuroblastoma SH-SY5Y cells.

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