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Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers

Ahmed E.M. Mekky 1
Ahmed E.M. Mekky
, 
Sherif M.H. Sanad 1
Sherif M.H. Sanad
1 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
10.1016/j.mencom.2023.04.011
Published 2023-04-13
Communication , Volume 33, Issue 3, 331-333
9
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Mekky A. E., Sanad S. M. Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 331-333.
GOST all authors (up to 50) Copy
Mekky A. E., Sanad S. M. Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 331-333.
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TY - JOUR
DO - 10.1016/j.mencom.2023.04.011
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.011
TI - Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers
T2 - Mendeleev Communications
AU - Mekky, Ahmed E.M.
AU - Sanad, Sherif M.H.
PY - 2023
DA - 2023/04/13
PB - Mendeleev Communications
SP - 331-333
IS - 3
VL - 33
ER -
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@article{2023_Mekky,
author = {Ahmed E.M. Mekky and Sherif M.H. Sanad},
title = {Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.011},
number = {3},
pages = {331--333},
doi = {10.1016/j.mencom.2023.04.011}
}
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Mekky, Ahmed E.M., and Sherif M.H. Sanad. “Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers.” Mendeleev Communications, vol. 33, no. 3, Apr. 2023, pp. 331-333. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.011.

Keywords

1 3-dielectrophiles
aza-Michael addition
bis(aldehyde)
heterocyclization
in vitro antibacterial screening
multicomponent reactions
pyrazolo[1,5-a]pyrimidine
α-unsaturated nitriles

Abstract

A three-component protocol was adopted to efficiently prepare new bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers in 80-92% yields from 1H-pyrazole-3,5-diamines, malononitrile and bis(aldehydes). The p-xylene-linked bis(pyrimidine) bearing 3-positioned 4-methoxy-benzyl substituent had the best antibacterial activity with MIC / MBC values up to 2.2 / 4.4 µm.

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