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Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties

Anastasiya Iosifovna Govdi 1
Anastasiya Iosifovna Govdi
, 
Sergey O Anisimov 2
Sergey O Anisimov
, 
Natalya A Danilkina 1
Natalya A Danilkina
, 
Alexander Siyasatovich Bunev 3
Alexander Siyasatovich Bunev
, 
Irina Anatol'evna Balova 1
Irina Anatol'evna Balova
1 Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
2 St. Petersburg State Chemical and Pharmaceutical University, St. Petersburg, Russian Federation
3 Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation
10.1016/j.mencom.2023.04.010
Published 2023-04-13
Communication , Volume 33, Issue 3, 328-330
5
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Govdi A. I. et al. Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 328-330.
GOST all authors (up to 50) Copy
Govdi A. I., Anisimov S. O., Danilkina N. A., Bunev A. S., Balova I. A. Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties // Mendeleev Communications. 2023. Vol. 33. No. 3. pp. 328-330.
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TY - JOUR
DO - 10.1016/j.mencom.2023.04.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.010
TI - Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties
T2 - Mendeleev Communications
AU - Govdi, Anastasiya Iosifovna
AU - Anisimov, Sergey O
AU - Danilkina, Natalya A
AU - Bunev, Alexander Siyasatovich
AU - Balova, Irina Anatol'evna
PY - 2023
DA - 2023/04/13
PB - Mendeleev Communications
SP - 328-330
IS - 3
VL - 33
ER -
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@article{2023_Govdi,
author = {Anastasiya Iosifovna Govdi and Sergey O Anisimov and Natalya A Danilkina and Alexander Siyasatovich Bunev and Irina Anatol'evna Balova},
title = {Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.010},
number = {3},
pages = {328--330},
doi = {10.1016/j.mencom.2023.04.010}
}
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Govdi, Anastasiya Iosifovna, et al. “Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties.” Mendeleev Communications, vol. 33, no. 3, Apr. 2023, pp. 328-330. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.04.010.

Keywords

1
2
3-triazoles
benzothiophene
cytotoxicity.
enediynes
Heterocycles
Mannich reaction
propargylamines
Sonogashira reaction

Abstract

Synthesis of 3-(5-triazolyl)- and 3-(3-benzothienyl)-propargylamines includes the Mannich reaction of the corresponding ethynyl derivatives with diaminomethanes. The MTT test of the synthesized compounds toward the viability of NCI-H460 lung carcinoma cells and WI-26 VA4 normal lung fibroblast cells reveals one of them possessing a notable cytotoxic activity.

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