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Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

, 
Irina I Ivanova 1
Irina I Ivanova
,  , 
Dmitry Vladimirovich Konev 1
Dmitry Vladimirovich Konev
, 
Vladimir Alexandrovich Kurmaz 1
Vladimir Alexandrovich Kurmaz
, 
Natalia Vladimirovna Filatova 1
Natalia Vladimirovna Filatova
, 
Anastasya Aleksandrovna Balakina 1
Anastasya Aleksandrovna Balakina
, 
Alexei Alekseevich Terentyev 1, 2, 3
Alexei Alekseevich Terentyev
1 Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
2 Department of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
3 Moscow Region State Pedagogical University, Mytishi, Moscow Region, Russian Federation
10.1016/j.mencom.2023.02.034
Published 2023-02-13
Communication , Volume 33, Issue 2, 255-258
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Kurmaz S. V. et al. Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 255-258.
GOST all authors (up to 50) Copy
Kurmaz S. V., Ivanova I. I., Emelyanova N. S., Konev D. V., Kurmaz V. A., Filatova N. V., Balakina A. A., Terentyev A. A. Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 255-258.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.034
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.034
TI - Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate
T2 - Mendeleev Communications
AU - Kurmaz, Svetlana Viktorovna
AU - Ivanova, Irina I
AU - Emelyanova, Nina Sergeevna
AU - Konev, Dmitry Vladimirovich
AU - Kurmaz, Vladimir Alexandrovich
AU - Filatova, Natalia Vladimirovna
AU - Balakina, Anastasya Aleksandrovna
AU - Terentyev, Alexei Alekseevich
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 255-258
IS - 2
VL - 33
ER -
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@article{2023_Kurmaz,
author = {Svetlana Viktorovna Kurmaz and Irina I Ivanova and Nina Sergeevna Emelyanova and Dmitry Vladimirovich Konev and Vladimir Alexandrovich Kurmaz and Natalia Vladimirovna Filatova and Anastasya Aleksandrovna Balakina and Alexei Alekseevich Terentyev},
title = {Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.034},
number = {2},
pages = {255--258},
doi = {10.1016/j.mencom.2023.02.034}
}
MLA
Cite this
MLA Copy
Kurmaz, Svetlana Viktorovna, et al. “Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 255-258. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.034.

Keywords

cyclic voltammetry
cytotoxicity.
doxorubicin
N-vinylpyrrolidone
quantum chemical modeling
terpolymer
triethylene glycol dimethacrylate

Abstract

Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH and NH+ groups form hydrogen bonds. The compositions have lower cytotoxicity in vitro compared with that of free doxorubicin

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