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Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block

Yuliia Evgenievna Kuzmina 1
Yuliia Evgenievna Kuzmina
, 
Zaret Gezimahmaevna Denieva 2
Zaret Gezimahmaevna Denieva
, 
Maria Sergeevna Zolotareva 1
Maria Sergeevna Zolotareva
, 
Ul'yana Alexandrovna Budanova 1
Ul'yana Alexandrovna Budanova
, 
Yurii Lvovich Sebyakin 1
Yurii Lvovich Sebyakin
1 M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
2 A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russian Federation
10.1016/j.mencom.2023.02.029
Published 2023-02-13
Communication , Volume 33, Issue 2, 240-242
2
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Kuzmina Y. E. et al. Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 240-242.
GOST all authors (up to 50) Copy
Kuzmina Y. E., Denieva Z. G., Zolotareva M. S., Budanova U. A., Sebyakin Y. L. Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 240-242.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.029
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.029
TI - Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block
T2 - Mendeleev Communications
AU - Kuzmina, Yuliia Evgenievna
AU - Denieva, Zaret Gezimahmaevna
AU - Zolotareva, Maria Sergeevna
AU - Budanova, Ul'yana Alexandrovna
AU - Sebyakin, Yurii Lvovich
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 240-242
IS - 2
VL - 33
ER -
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@article{2023_Kuzmina,
author = {Yuliia Evgenievna Kuzmina and Zaret Gezimahmaevna Denieva and Maria Sergeevna Zolotareva and Ul'yana Alexandrovna Budanova and Yurii Lvovich Sebyakin},
title = {Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.029},
number = {2},
pages = {240--242},
doi = {10.1016/j.mencom.2023.02.029}
}
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Kuzmina, Yuliia Evgenievna, et al. “Cationic amphiphiles based on diethanolamine esters with amino acids in the polar block.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 240-242. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.029.

Keywords

Antibacterial activity
antimicrobial peptidomimetics
cationic amphiphiles
diethanolamine esters
dipeptides

Abstract

A series of new cationic amphiphiles based on diethanolamine esters with Gly, βAla, GABA, Lys, Orn amino acid residues in the hydrophilic block were prepared. The sample containing the Lys residue showed the best activity against gram-positive and gram-negative bacteria. For model membranes comprising combinations of DOPC, DOPG and DOPE phospholipids, the sample can electrostatically bind to the surface of a bacterial cell and destroy it by formation of through defects.

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