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Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue

Roman Sergeevich Begunov 1
Roman Sergeevich Begunov
,  , 
Ekaterina Yur'evna Yandulova 2
Ekaterina Yur'evna Yandulova
, 
Natalia Sergeevna Nikolaeva 2
Natalia Sergeevna Nikolaeva
, 
1 P.G. Demidov Yaroslavl State University, Yaroslavl, Russian Federation
2 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
10.1016/j.mencom.2023.02.028
Published 2023-02-13
Communication , Volume 33, Issue 2, 237-239
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Begunov R. S. et al. Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 237-239.
GOST all authors (up to 50) Copy
Begunov R. S., Aleksandrova Y. R., Yandulova E. Y., Nikolaeva N. S., Neganova M. E. Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 237-239.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.028
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.028
TI - Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue
T2 - Mendeleev Communications
AU - Begunov, Roman Sergeevich
AU - Aleksandrova, Yulia Romanovna
AU - Yandulova, Ekaterina Yur'evna
AU - Nikolaeva, Natalia Sergeevna
AU - Neganova, Margarita Evgenievna
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 237-239
IS - 2
VL - 33
ER -
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@article{2023_Begunov,
author = {Roman Sergeevich Begunov and Yulia Romanovna Aleksandrova and Ekaterina Yur'evna Yandulova and Natalia Sergeevna Nikolaeva and Margarita Evgenievna Neganova},
title = {Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.028},
number = {2},
pages = {237--239},
doi = {10.1016/j.mencom.2023.02.028}
}
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Begunov, Roman Sergeevich, et al. “Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 237-239. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.028.

Keywords

2-a]benzimidazole-6
2-bromo-3-chloro-1
4-benzoquinones
9-diones
cytotoxicity.
flow-through catalytic hydrogenation
hetero- cyclization
intramolecular reductive reactions
prooxidant activity
pyrido[1

Abstract

An efficient synthesis of 8-bromo-7-chloropyrido[1,2-a]-benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue from N-(4-chloro-2-nitrophenyl)pyridinium chloride has been accomplished. The study for antitumour activity against cancer cell lines such as A549, SH-SY5Y, Hep-2, HeLa and MCF-7 revealed that the cytotoxic effect of the compounds obtained was several times higher than that of Mitomycin C.

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