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Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes

Tatiana Petrovna Trofimova 1, 2
Tatiana Petrovna Trofimova
, 
Fedor Sergeyevich Chikunov 1
Fedor Sergeyevich Chikunov
, 
Alexey N Proshin 2
Alexey N Proshin
, 
Alexey Sergeyevich Borodkov 3
Alexey Sergeyevich Borodkov
, 
Marina Alekseevna Orlova 1, 4
Marina Alekseevna Orlova
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
3 V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
4 N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
10.1016/j.mencom.2023.02.016
Published 2023-02-13
Communication , Volume 33, Issue 2, 201-202
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Trofimova T. P. et al. Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 201-202.
GOST all authors (up to 50) Copy
Trofimova T. P., Chikunov F. S., Proshin A. N., Borodkov A. S., Orlova M. A. Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 201-202.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.016
TI - Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes
T2 - Mendeleev Communications
AU - Trofimova, Tatiana Petrovna
AU - Chikunov, Fedor Sergeyevich
AU - Proshin, Alexey N
AU - Borodkov, Alexey Sergeyevich
AU - Orlova, Marina Alekseevna
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 201-202
IS - 2
VL - 33
ER -
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@article{2023_Trofimova,
author = {Tatiana Petrovna Trofimova and Fedor Sergeyevich Chikunov and Alexey N Proshin and Alexey Sergeyevich Borodkov and Marina Alekseevna Orlova},
title = {Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.016},
number = {2},
pages = {201--202},
doi = {10.1016/j.mencom.2023.02.016}
}
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Trofimova, Tatiana Petrovna, et al. “Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 201-202. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.016.

Keywords

2
4-thiadiazoles
5-anilino-1
cardiotoxicity
cytotoxicity
leukemic cell lines.
radiation stability
zinc complexes

Abstract

A new polyfunctional ligand of the thiadiazole family was synthesized. Cytotoxic properties with respect to leukemic cell lines, radiation stability, predicted permeability through the blood-brain barrier and cardiotoxicity of the new ligand and its precursor were determined. New zinc complexes with N-{2-[5-(3-chloro-4-methylphenylamino)-1,2,4-thiadiazol-3-yl]-1-methylethyl}-N-(2,2,6,6-tetramethylpiperidin-4-yl)-amine as the ligand have been obtained.

References

.
Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles
Castro A., Castaño T., Encinas A., Porcal W., Gil C.
Bioorganic and Medicinal Chemistry, 2006
.
DRUG SENSITIVITY ASSAYS IN LEUKAEMIA AND LYMPHOMA
Veerman A.J., Pieters R.
British Journal of Haematology, 1990
.
Orlova M.
British Journal of Medicine and Medical Research, 2012
.
Transition metals, their organic complexes, and radionuclides promising for medical use
Orlov A.P., Trofimova T.P., Orlova M.A.
Russian Chemical Bulletin, 2022
.
Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
Orlova M.A., Trofimova T.P., Proshin A.N., Orlov A.P.
Russian Chemical Bulletin, 2017
.
Gas-phase basicity: Parameter determining the efficiency of laser desorption/ionization from silicon surfaces
Grechnikov A.A., Borodkov A.S., Alimpiev S.S., Nikiforov S.M., Simanovsky Y.O.
Journal of Analytical Chemistry, 2012
.
Copper Compounds in Anticancer Strategies
Tardito S., Marchio L.
Current Medicinal Chemistry, 2009
.
Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles
Kumar D., Kumar N.M., Chang K., Gupta R., Shah K.
Bioorganic and Medicinal Chemistry Letters, 2011
.
hERG toxicity assessment: Useful guidelines for drug design
Garrido A., Lepailleur A., Mignani S.M., Dallemagne P., Rochais C.
European Journal of Medicinal Chemistry, 2020