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Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane

Alexander Mikhailovich Demin 1
Alexander Mikhailovich Demin
, 
Alexander Victorovich Vakhrushev 1
Alexander Victorovich Vakhrushev
, 
Marina Sergeevna Valova 1
Marina Sergeevna Valova
, 
Marina Anatol'evna Korolyova 1
Marina Anatol'evna Korolyova
, 
Mikhail Alexandrovich Uimin 2
Mikhail Alexandrovich Uimin
, 
Artem Sergeevich Minin 2
Artem Sergeevich Minin
, 
Konstantin Andreevich Chistyakov 1
Konstantin Andreevich Chistyakov
, 
Victor Pavlovich Krasnov 1
Victor Pavlovich Krasnov
, 
1 I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
2 M.N. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
10.1016/j.mencom.2023.02.004
Published 2023-02-13
Communication , Volume 33, Issue 2, 160-163
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Demin A. M. et al. Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 160-163.
GOST all authors (up to 50) Copy
Demin A. M., Vakhrushev A. V., Valova M. S., Korolyova M. A., Uimin M. A., Minin A. S., Chistyakov K. A., Krasnov V. P., Charushin V. N. Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 160-163.
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TY - JOUR
DO - 10.1016/j.mencom.2023.02.004
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.004
TI - Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane
T2 - Mendeleev Communications
AU - Demin, Alexander Mikhailovich
AU - Vakhrushev, Alexander Victorovich
AU - Valova, Marina Sergeevna
AU - Korolyova, Marina Anatol'evna
AU - Uimin, Mikhail Alexandrovich
AU - Minin, Artem Sergeevich
AU - Chistyakov, Konstantin Andreevich
AU - Krasnov, Victor Pavlovich
AU - Charushin, Valery Nikolaevich
PY - 2023
DA - 2023/02/13
PB - Mendeleev Communications
SP - 160-163
IS - 2
VL - 33
ER -
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@article{2023_Demin,
author = {Alexander Mikhailovich Demin and Alexander Victorovich Vakhrushev and Marina Sergeevna Valova and Marina Anatol'evna Korolyova and Mikhail Alexandrovich Uimin and Artem Sergeevich Minin and Konstantin Andreevich Chistyakov and Victor Pavlovich Krasnov and Valery Nikolaevich Charushin},
title = {Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {Mendeleev Communications},
month = {Feb},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.004},
number = {2},
pages = {160--163},
doi = {10.1016/j.mencom.2023.02.004}
}
MLA
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Demin, Alexander Mikhailovich, et al. “Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane.” Mendeleev Communications, vol. 33, no. 2, Feb. 2023, pp. 160-163. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.02.004.

Keywords

DFT.
doxorubicin
magnetic nanoparticles
Nanocomposites
PMIDA
silica coating
surface functionalization

Abstract

New nanocomposites based on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane (APS), including those using N-(phosphonomethyl)iminodiacetic acid (PMIDA), were obtained, and the immobilization of the antitumor agent doxorubicin (Dox) on nanocomposites was examined. It has been shown that the binding of Dox to the negatively charged surface of SiO2 particles occurs more efficiently than that to the APS-modified surface with positively charged amino groups; the presence of PMIDA molecules on the surface significantly increased the loading content. Based on DFT calculations, a mechanism for Dox binding to the surface of the synthesized nanocomposites was proposed.

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