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Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane

Elena Borisovna Rakhimova 1
Elena Borisovna Rakhimova
,  , 
Ulyana Sh Kuzmina 2
Ulyana Sh Kuzmina
, 
Ilgiz V Galyautdinov 2
Ilgiz V Galyautdinov
, 
Yulia Venerovna Vakhitova 2
Yulia Venerovna Vakhitova
1 Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
2 Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation
10.1016/j.mencom.2023.01.035
Published 2022-12-26
Communication , Volume 33, Issue 1, 112-114
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Rakhimova E. B. et al. Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 112-114.
GOST all authors (up to 50) Copy
Rakhimova E. B., Kirsanov V. Y., Kuzmina U. S., Galyautdinov I. V., Vakhitova Y. V. Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 112-114.
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TY - JOUR
DO - 10.1016/j.mencom.2023.01.035
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.035
TI - Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane
T2 - Mendeleev Communications
AU - Rakhimova, Elena Borisovna
AU - Kirsanov, Victor Yuryevich
AU - Kuzmina, Ulyana Sh
AU - Galyautdinov, Ilgiz V
AU - Vakhitova, Yulia Venerovna
PY - 2022
DA - 2022/12/26
PB - Mendeleev Communications
SP - 112-114
IS - 1
VL - 33
ER -
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@article{2022_Rakhimova,
author = {Elena Borisovna Rakhimova and Victor Yuryevich Kirsanov and Ulyana Sh Kuzmina and Ilgiz V Galyautdinov and Yulia Venerovna Vakhitova},
title = {Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane},
journal = {Mendeleev Communications},
year = {2022},
volume = {33},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.035},
number = {1},
pages = {112--114},
doi = {10.1016/j.mencom.2023.01.035}
}
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Rakhimova, Elena Borisovna, et al. “Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane.” Mendeleev Communications, vol. 33, no. 1, Dec. 2022, pp. 112-114. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.035.
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Keywords

2-diaminocyclohexane
anilines
catalysis
cytotoxic activity.
heterocyclization
hexaazadibenzotetracenes
polycyclic compounds
trans-1

Abstract

A one-pot synthesis of N,N'-disubstituted (3bR*,7aR*,10bR*,14aR*)-octadecahydro-1H ,8H-2,3a,7b,9,10a,14b-hexaazadibenzo[fg, op]tetracenes via the catalytic heterocyclization of trans-1,6,7,12-tetraaza-perhydrotetracene with formaldehyde or CH2(NMe2)2 and anilines has been accomplished. Preliminary screening of thus obtained perhydro hexaazadibenzotetracenes for cytotoxic activity has been performed.

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