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Urea derivatives of spirocyclic piperidines endowed with antibacterial activity

Alexei Yur'evich Lukin 1
Alexei Yur'evich Lukin
, 
Kristina Yuryevna Komarova 1
Kristina Yuryevna Komarova
, 
Lyubov V Vinogradova 1
Lyubov V Vinogradova
, 
Elizaveta Vladimirovna Rogacheva 2
Elizaveta Vladimirovna Rogacheva
, 
Lyudmila Aleksandrovna Kraeva 2
Lyudmila Aleksandrovna Kraeva
, 
Marine Dogonadge 3
Marine Dogonadge
, 
Tatiana Vinogradova 3
Tatiana Vinogradova
, 
Mikhail Yur'evich Krasavin 4, 5
Mikhail Yur'evich Krasavin
1 M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
2 St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
3 St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation
4 Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
5 Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
10.1016/j.mencom.2023.01.034
Published 2022-12-26
Communication , Volume 33, Issue 1, 109-111
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Lukin A. Y. et al. Urea derivatives of spirocyclic piperidines endowed with antibacterial activity // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 109-111.
GOST all authors (up to 50) Copy
Lukin A. Y., Komarova K. Y., Vinogradova L. V., Rogacheva E. V., Kraeva L. A., Dogonadge M., Vinogradova T., Krasavin M. Y. Urea derivatives of spirocyclic piperidines endowed with antibacterial activity // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 109-111.
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TY - JOUR
DO - 10.1016/j.mencom.2023.01.034
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.034
TI - Urea derivatives of spirocyclic piperidines endowed with antibacterial activity
T2 - Mendeleev Communications
AU - Lukin, Alexei Yur'evich
AU - Komarova, Kristina Yuryevna
AU - Vinogradova, Lyubov V
AU - Rogacheva, Elizaveta Vladimirovna
AU - Kraeva, Lyudmila Aleksandrovna
AU - Dogonadge, Marine
AU - Vinogradova, Tatiana
AU - Krasavin, Mikhail Yur'evich
PY - 2022
DA - 2022/12/26
PB - Mendeleev Communications
SP - 109-111
IS - 1
VL - 33
ER -
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@article{2022_Lukin,
author = {Alexei Yur'evich Lukin and Kristina Yuryevna Komarova and Lyubov V Vinogradova and Elizaveta Vladimirovna Rogacheva and Lyudmila Aleksandrovna Kraeva and Marine Dogonadge and Tatiana Vinogradova and Mikhail Yur'evich Krasavin},
title = {Urea derivatives of spirocyclic piperidines endowed with antibacterial activity},
journal = {Mendeleev Communications},
year = {2022},
volume = {33},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.034},
number = {1},
pages = {109--111},
doi = {10.1016/j.mencom.2023.01.034}
}
MLA
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MLA Copy
Lukin, Alexei Yur'evich, et al. “Urea derivatives of spirocyclic piperidines endowed with antibacterial activity.” Mendeleev Communications, vol. 33, no. 1, Dec. 2022, pp. 109-111. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.034.
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Keywords

antibacterial activity.
antimycobacterial activity
epoxide hydrolase
membrane transporter Mmpl3
piperidines
spirocyclic compounds
ureas

Abstract

Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria.

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