Home / Publications / Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution

Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution

Anastasiia M Desyatskova 1
Anastasiia M Desyatskova
, 
Ekaterina Vladimirovna Kuznetsova 1
Ekaterina Vladimirovna Kuznetsova
, 
Yulia Alexeevna Puchkova 1, 2
Yulia Alexeevna Puchkova
, 
Evgeny Victorovich Yastremsky 1, 3
Evgeny Victorovich Yastremsky
, 
Artem Vadimovich Bakirov 1, 2
Artem Vadimovich Bakirov
, 
Petr Vladimirovich Dmitryakov 1
Petr Vladimirovich Dmitryakov
, 
Alexander Igorevich Buzin 2
Alexander Igorevich Buzin
, 
Sergei Nikolaevich Chvalun 1, 2
Sergei Nikolaevich Chvalun
1 National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
2 N.S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow, Russian Federation
3 A.V. Shubnikov Institute of Crystallography, FSRC ‘Crystallography and Photonics', Russian Academy of Sciences, Moscow, Russian Federaion
10.1016/j.mencom.2023.01.027
Published 2022-12-26
Communication , Volume 33, Issue 1, 86-89
6
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Desyatskova A. M. et al. Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 86-89.
GOST all authors (up to 50) Copy
Desyatskova A. M., Kuznetsova E. V., Puchkova Y. A., Yastremsky E. V., Bakirov A. V., Dmitryakov P. V., Buzin A. I., Chvalun S. N. Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 86-89.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.01.027
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.027
TI - Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution
T2 - Mendeleev Communications
AU - Desyatskova, Anastasiia M
AU - Kuznetsova, Ekaterina Vladimirovna
AU - Puchkova, Yulia Alexeevna
AU - Yastremsky, Evgeny Victorovich
AU - Bakirov, Artem Vadimovich
AU - Dmitryakov, Petr Vladimirovich
AU - Buzin, Alexander Igorevich
AU - Chvalun, Sergei Nikolaevich
PY - 2022
DA - 2022/12/26
PB - Mendeleev Communications
SP - 86-89
IS - 1
VL - 33
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Desyatskova,
author = {Anastasiia M Desyatskova and Ekaterina Vladimirovna Kuznetsova and Yulia Alexeevna Puchkova and Evgeny Victorovich Yastremsky and Artem Vadimovich Bakirov and Petr Vladimirovich Dmitryakov and Alexander Igorevich Buzin and Sergei Nikolaevich Chvalun},
title = {Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution},
journal = {Mendeleev Communications},
year = {2022},
volume = {33},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.027},
number = {1},
pages = {86--89},
doi = {10.1016/j.mencom.2023.01.027}
}
MLA
Cite this
MLA Copy
Desyatskova, Anastasiia M., et al. “Effect of stereocomplex formation between enantiomeric poly(L,L-lactide) and poly(D,D-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution.” Mendeleev Communications, vol. 33, no. 1, Dec. 2022, pp. 86-89. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.027.
Views
1

Keywords

amphiphilic block copolymers
block copolymer micelles
drug delivery systems.
poly(ethylene oxide)
poly(lactide)
self-organization
stereocomplex formation

Abstract

The effect of crystallization of a hydrophobic poly(lactide) block on the self-organization of biocompatible and biodegradable amphiphilic poly(lactide)-block-poly(ethylene oxide) (PLA-b-PEO) copolymers in a dilute aqueous solution has been investigated. It was demonstrated that the co-crystallization of poly(L,L-lactide) [P(L,L)LA] and poly(d,d-lactide) [P(d,d)LA] chains under equimolar mixing of P(L,L)LA46-b-PEO113 and P(d,d)LA56-b-PEO113 copolymers resulted in the formation of stable and spontaneously water-redispersible stereocomplex micelles with semicrystalline P(L,L)LA/P(d,d)LA cores. It was shown that the P(L,L)LA46 / P(d,d)LA56-b-PEO113 stereo-complex micelles produced by dialysis can be potential vehicles for the anticancer agent oxaliplatin

References

.
Encapsulation of a hydrophobic drug into a polymer-micelle core explored with synchrotron SAXS.
Akiba I., Terada N., Hashida S., Sakurai K., Sato T., Shiraishi K., Yokoyama M., Masunaga H., Ogawa H., Ito K., Yagi N.
Langmuir, 2010
.
Different insight into amphiphilic PEG-PLA copolymers: influence of macromolecular architecture on the micelle formation and cellular uptake.
Garofalo C., Capuano G., Sottile R., Tallerico R., Adami R., Reverchon E., Carbone E., Izzo L., Pappalardo D.
Biomacromolecules, 2013
.
Aggregation behavior of self-assembling polylactide/poly(ethylene glycol) micelles for sustained drug delivery.
Yang L., Qi X., Liu P., El Ghzaoui A., Li S.
International Journal of Pharmaceutics, 2010
.
Effect of Composition and Molecular Structure of Poly(l-lactic acid)/Poly(ethylene oxide) Block Copolymers on Micellar Morphology in Aqueous Solution
Razuvaeva E.V., Kulebyakina A.I., Streltsov D.R., Bakirov A.V., Kamyshinsky R.A., Kuznetsov N.M., Chvalun S.N., Shtykova E.V.
Langmuir, 2018
.
Self-assembled filomicelles prepared from polylactide/poly(ethylene glycol) block copolymers for anticancer drug delivery
Jelonek K., Li S., Wu X., Kasperczyk J., Marcinkowski A.
International Journal of Pharmaceutics, 2015
.
Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin
Kadina Y.A., Razuvaeva E.V., Streltsov D.R., Sedush N.G., Shtykova E.V., Kulebyakina A.I., Puchkov A.A., Volkov D.S., Nazarov A.A., Chvalun S.N.
Molecules, 2021
.
Mechanism of the Stereocomplex Formation between Enantiomeric Poly(lactide)s
Brizzolara D., Cantow H., Diederichs K., Keller E., Domb A.J.
Macromolecules, 1996
.
Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles
Riley T., Stolnik S., Heald C.R., Xiong C.D., Garnett M.C., Illum L., Davis S.S., Purkiss S.C., Barlow R.J., Gellert P.R.
Langmuir, 2001
.
Crystal Modifications and Thermal Behavior of Poly(l-lactic acid) Revealed by Infrared Spectroscopy
Zhang J., Duan Y., Sato H., Tsuji H., Noda I., Yan S., Ozaki Y.
Macromolecules, 2005
.
Stereocomplex Block Copolymer Micelles:  Core−Shell Nanostructures with Enhanced Stability
Kang N., Perron M., Prud'homme R.E., Zhang Y., Gaucher G., Leroux J.
Nano Letters, 2005
.
Block Copolymer Stereoregularity and Its Impact on Polymeric Micellar Nanodrug Delivery
Soleymani Abyaneh H., Vakili M.R., Shafaati A., Lavasanifar A.
Molecular Pharmaceutics, 2017
.
Polylactide-Based Amphiphilic Block Copolymers: Crystallization-Induced Self-Assembly and Stereocomplexation
Noack S., Schanzenbach D., Koetz J., Schlaad H.
Macromolecular Rapid Communications, 2018
.
Stereocomplex micelle loaded with paclitaxel for enhanced therapy of breast cancer in an orthotopic mouse model
Piao L., Li Y., Zhang H., Jiang J.
Journal of Biomaterials Science, Polymer Edition, 2019
.
Role of hydrolytic degradation of polylactide drug carriers in developing micro- and nanoscale polylactide-based drug dosage forms
Ermolenko Y.V., Semyonkin A.S., Ulianova Y.V., Kovshova T.S., Maksimenko O.O., Gelperina S.E.
Russian Chemical Bulletin, 2020
.
Aggregation in Biocompatible Linear Block Copolymers: Computer Simulation Study
Dolgov D.S., Grigor’ev T.E., Kulebyakina A.I., Razuvaeva E.V., Gumerov R.A., Chvalun S.N., Potemkin I.I.
Polymer Science - Series A, 2018
.
Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures
Sedush N.G., Kadina Y.A., Razuvaeva E.V., Puchkov A.A., Shirokova E.M., Gomzyak V.I., Kalinin K.T., Kulebyakina A.I., Chvalun S.N.
Nanobiotechnology Reports, 2021
.
Enantiomeric PLA–PEG block copolymers and their stereocomplex micelles used as rifampin delivery
Chen L., Xie Z., Hu J., Chen X., Jing X.
Journal of Nanoparticle Research, 2006
.
Methoxy poly(ethylene glycol)/?-caprolactone amphiphilic block copolymeric micelle containing indome
Gyun Shin I., Yeon Kim S., Moo Lee Y., Soo Cho C., Yong Kiel Sung
Journal of Controlled Release, 1998
.
Bioresorbable filomicelles for targeted delivery of betulin derivative – In vitro study
Jelonek K., Kasperczyk J., Li S., Nguyen T.H., Orchel A., Chodurek E., Paduszyński P., Jaworska-Kik M., Chrobak E., Bębenek E., Boryczka S., Jarosz-Biej M., Smolarczyk R., Foryś A.
International Journal of Pharmaceutics, 2019
.
Razuvaeva E.V., Kalinin K.T., Sedush N.G., Nazarov A.A., Volkov D.S., Chvalun S.N.
Mendeleev Communications, 2021
.
Morphogenic effect of common solvent in the self-assembly behavior of amphiphilic PEO-b-PLA
Simonutti R., Bertani D., Marotta R., Ferrario S., Manzone D., Mauri M., Gregori M., Orlando A., Masserini M.
Polymer, 2021