Home / Publications / New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system

New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system

Elena Andreevna Golubeva 1
Elena Andreevna Golubeva
, 
Mstislav Igorevich Lavrov 1
Mstislav Igorevich Lavrov
,  , 
Evgenia Mikhailovna Bovina 1
Evgenia Mikhailovna Bovina
, 
Eugene V Radchenko 1
Eugene V Radchenko
,  , 
Andrey Fedorovich Asachenko 2
Andrey Fedorovich Asachenko
, 
Vladimir Lollievich Zamoyski 3
Vladimir Lollievich Zamoyski
, 
Vladimir Viktorovich Grigoriev 1, 3
Vladimir Viktorovich Grigoriev
, 
Vladimir Alexandrovich Palyulin 1
Vladimir Alexandrovich Palyulin
1 Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
2 A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
3 Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
10.1016/j.mencom.2023.01.022
Published 2022-12-26
Communication , Volume 33, Issue 1, 70-72
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Golubeva E. A. et al. New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 70-72.
GOST all authors (up to 50) Copy
Golubeva E. A., Lavrov M. I., Veremeeva P. N., Bovina E. M., Radchenko E. V., Topchiy M. A., Asachenko A. F., Zamoyski V. L., Grigoriev V. V., Palyulin V. A. New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 70-72.
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TY - JOUR
DO - 10.1016/j.mencom.2023.01.022
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.022
TI - New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system
T2 - Mendeleev Communications
AU - Golubeva, Elena Andreevna
AU - Lavrov, Mstislav Igorevich
AU - Veremeeva, Polina Nikolaevna
AU - Bovina, Evgenia Mikhailovna
AU - Radchenko, Eugene V
AU - Topchiy, Maxim Anatol'evich
AU - Asachenko, Andrey Fedorovich
AU - Zamoyski, Vladimir Lollievich
AU - Grigoriev, Vladimir Viktorovich
AU - Palyulin, Vladimir Alexandrovich
PY - 2022
DA - 2022/12/26
PB - Mendeleev Communications
SP - 70-72
IS - 1
VL - 33
ER -
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@article{2022_Golubeva,
author = {Elena Andreevna Golubeva and Mstislav Igorevich Lavrov and Polina Nikolaevna Veremeeva and Evgenia Mikhailovna Bovina and Eugene V Radchenko and Maxim Anatol'evich Topchiy and Andrey Fedorovich Asachenko and Vladimir Lollievich Zamoyski and Vladimir Viktorovich Grigoriev and Vladimir Alexandrovich Palyulin},
title = {New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system},
journal = {Mendeleev Communications},
year = {2022},
volume = {33},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.022},
number = {1},
pages = {70--72},
doi = {10.1016/j.mencom.2023.01.022}
}
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Golubeva, Elena Andreevna, et al. “New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system.” Mendeleev Communications, vol. 33, no. 1, Dec. 2022, pp. 70-72. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.022.
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Keywords

3
7-diazabicyclo[3.3.1]nonanes
allosteric modulators
AMPA receptor
cross-coupling
indane derivatives
nitriles
PAMs
patch clamp.
piperonylic acid

Abstract

An optimized synthesis of N-{5-[(1,11-dimethyl-4,8,12-trioxo-3,6,9-triazatricyclo[7.3.1.13,11]tetradec-6-yl)methyl]-indan-2-yl}-1,3-benzodioxole-5-carboxamide has been carried out from indan-2-one oxime in seven steps. In vitro studies using electrophysiological patch clamp technique have revealed a positive modulation effect of this compound on kainate induced currents in Purkinje neurons in a wide range of concentrations from 10-12 to 10-8 m.

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