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Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis

, 
Alexey Anatol'evich Tsygankov 1
Alexey Anatol'evich Tsygankov
,  , 
Denis Alexandrovich Chusov 1, 2
Denis Alexandrovich Chusov
1 A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
2 G.V. Plekhanov Russian University of Economics, Moscow, Russian Federation
10.1016/j.mencom.2023.01.005
Published 2022-12-26
Communication , Volume 33, Issue 1, 17-20
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Runikhina S. A. et al. Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 17-20.
GOST all authors (up to 50) Copy
Runikhina S. A., Tsygankov A. A., Afanasyev O. I., Chusov D. A. Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis // Mendeleev Communications. 2022. Vol. 33. No. 1. pp. 17-20.
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TY - JOUR
DO - 10.1016/j.mencom.2023.01.005
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.005
TI - Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis
T2 - Mendeleev Communications
AU - Runikhina, Sofiya Alexandrovna
AU - Tsygankov, Alexey Anatol'evich
AU - Afanasyev, Oleg Ilyich
AU - Chusov, Denis Alexandrovich
PY - 2022
DA - 2022/12/26
PB - Mendeleev Communications
SP - 17-20
IS - 1
VL - 33
ER -
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@article{2022_Runikhina,
author = {Sofiya Alexandrovna Runikhina and Alexey Anatol'evich Tsygankov and Oleg Ilyich Afanasyev and Denis Alexandrovich Chusov},
title = {Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis},
journal = {Mendeleev Communications},
year = {2022},
volume = {33},
publisher = {Mendeleev Communications},
month = {Dec},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.005},
number = {1},
pages = {17--20},
doi = {10.1016/j.mencom.2023.01.005}
}
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Runikhina, Sofiya Alexandrovna, et al. “Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis.” Mendeleev Communications, vol. 33, no. 1, Dec. 2022, pp. 17-20. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2023.01.005.
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Keywords

aldehydes
aldol reaction
carbon monoxide
fluoride activation
Ketones
reductive addition
ruthenium

Abstract

Fluoride additive to [(p-cymene)RuCl2]2, a readily available ruthenium catalyst, allows one to achieve milder conditions for the reductive alkylation of aldehydes with ketones using carbon monoxide as a reducing agent. The procedure is suitable for the broad substrate scope, and a probable explanation for the fluoride role was provided.

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