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Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles

Anindita Mukherjee 1
Anindita Mukherjee
, 
Dmitrii Sergeevich Kopchuk 1, 2
Dmitrii Sergeevich Kopchuk
, 
Sougata Santra 1
Sougata Santra
, 
Adinath Majee 3
Adinath Majee
, 
Grigory Vasil'evich Zyryanov 1, 2
Grigory Vasil'evich Zyryanov
, 
Oleg Nikolaevich Chupakhin 1, 2
Oleg Nikolaevich Chupakhin
10.1016/j.mencom.2022.09.018
Published 2022-09-05
Communication , Volume 32, Issue 5, 624-626
7
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Mukherjee A. et al. Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 624-626.
GOST all authors (up to 50) Copy
Mukherjee A., Kopchuk D. S., Santra S., Majee A., Zyryanov G. V., Chupakhin O. N. Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 624-626.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.018
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.018
TI - Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles
T2 - Mendeleev Communications
AU - Mukherjee, Anindita
AU - Kopchuk, Dmitrii Sergeevich
AU - Santra, Sougata
AU - Majee, Adinath
AU - Zyryanov, Grigory Vasil'evich
AU - Chupakhin, Oleg Nikolaevich
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 624-626
IS - 5
VL - 32
ER -
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@article{2022_Mukherjee,
author = {Anindita Mukherjee and Dmitrii Sergeevich Kopchuk and Sougata Santra and Adinath Majee and Grigory Vasil'evich Zyryanov and Oleg Nikolaevich Chupakhin},
title = {Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.018},
number = {5},
pages = {624--626},
doi = {10.1016/j.mencom.2022.09.018}
}
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MLA Copy
Mukherjee, Anindita, et al. “Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 624-626. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.018.

Keywords

ball milling
cascade reactions
gram-scale synthesis
indoles
mechanochemical reactions
multi-substituted 3-(1H-pyrrol-2-yl)-1H-indoles
multicomponent reactions

Abstract

Iron(iii) chloride has been found to serve as an efficient catalyst for a mechanochemical (ball milling) one-pot four- component cascade reaction of phenyl glyoxal, anilines, indoles and activated alkyne affording highly-substituted 3-(1H-pyrrol-2-yl)-1H-indoles. The procedure is beneficial because of mild conditions, easily available starting materials, cheap catalyst and possibility for scaling.

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