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Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

Angelina Yu Bobrova 1
Angelina Yu Bobrova
, 
Maxim Alexandrovich Novikov 1
Maxim Alexandrovich Novikov
, 
Roman Aleksandrovich Novikov 1
Roman Aleksandrovich Novikov
, 
Pavel Vladimirovich Dorovatovskii 2
Pavel Vladimirovich Dorovatovskii
, 
Alexander Dmitrievich Volodin 3
Alexander Dmitrievich Volodin
, 
Alexander Aleksandrovich Korlyukov 3
Alexander Aleksandrovich Korlyukov
, 
10.1016/j.mencom.2022.09.016
Published 2022-09-05
Communication , Volume 32, Issue 5, 619-621
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Bobrova A. Yu. et al. Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 619-621.
GOST all authors (up to 50) Copy
Bobrova A. Yu., Novikov M. A., Novikov R. A., Dorovatovskii P. V., Volodin A. D., Korlyukov A. A., Tomilov Y. V. Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 619-621.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.016
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.016
TI - Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands
T2 - Mendeleev Communications
AU - Bobrova, Angelina Yu
AU - Novikov, Maxim Alexandrovich
AU - Novikov, Roman Aleksandrovich
AU - Dorovatovskii, Pavel Vladimirovich
AU - Volodin, Alexander Dmitrievich
AU - Korlyukov, Alexander Aleksandrovich
AU - Tomilov, Yury Vasil'evich
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 619-621
IS - 5
VL - 32
ER -
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@article{2022_Bobrova,
author = {Angelina Yu Bobrova and Maxim Alexandrovich Novikov and Roman Aleksandrovich Novikov and Pavel Vladimirovich Dorovatovskii and Alexander Dmitrievich Volodin and Alexander Aleksandrovich Korlyukov and Yury Vasil'evich Tomilov},
title = {Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.016},
number = {5},
pages = {619--621},
doi = {10.1016/j.mencom.2022.09.016}
}
MLA
Cite this
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Bobrova, Angelina Yu., et al. “Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 619-621. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.016.

Keywords

2-fluoroallyl amines
allylic amination
chiral palladium complexes
enantioselective catalysis
fluoroalkenes

Abstract

The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of η3-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P- and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.

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