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Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units

Ahmed E.M. Mekky 1
Ahmed E.M. Mekky
, 
Sherif M.H. Sanad 1
Sherif M.H. Sanad
, 
Ahmed M Abdelfattah 1
Ahmed M Abdelfattah
10.1016/j.mencom.2022.09.014
Published 2022-09-05
Communication , Volume 32, Issue 5, 612-614
19
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Mekky A. E., Sanad S. M., Abdelfattah A. M. Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 612-614.
GOST all authors (up to 50) Copy
Mekky A. E., Sanad S. M., Abdelfattah A. M. Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 612-614.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.014
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.014
TI - Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units
T2 - Mendeleev Communications
AU - Mekky, Ahmed E.M.
AU - Sanad, Sherif M.H.
AU - Abdelfattah, Ahmed M
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 612-614
IS - 5
VL - 32
ER -
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@article{2022_Mekky,
author = {Ahmed E.M. Mekky and Sherif M.H. Sanad and Ahmed M Abdelfattah},
title = {Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.014},
number = {5},
pages = {612--614},
doi = {10.1016/j.mencom.2022.09.014}
}
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Mekky, Ahmed E.M., et al. “Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 612-614. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.014.

Keywords

in vitro antibacterial screening
N-acylhydrazones
1,3,4-oxadiazoles
benzohydrazide
chloramine trihydrate
intramolecular cyclization
multicomponent reactions
oxidative cyclization
SwissADME prediction study
tandem reactions

Abstract

A three-component tandem protocol involving the reactions of bis(benzohydrazides), aromatic aldehydes and chloramine trihydrate yielded a new series of bis(1,3,4-oxadiazoles). The target hybrids were formed by an initial bis(N-benzoyl-hydrazones) formation, followed by chloramine trihydrate- mediated oxidative cyclization. The 4-methoxyphenyl-containing compounds demonstrated promising antibacterial activity against the Staphylococcus aureus and Pseudomonas aeruginosa strains with MIC value of 1.6 µm.

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