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Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene

Olga Ivanovna Yarovaya 1
Olga Ivanovna Yarovaya
, 
Kseniya Sergeevna Kovaleva 1
Kseniya Sergeevna Kovaleva
, 
Sophia Stanislavovna Borisevich 2
Sophia Stanislavovna Borisevich
, 
Tatyana Valeryevna Rybalova 1
Tatyana Valeryevna Rybalova
, 
Yuriy Vasil'evich Gatilov 1
Yuriy Vasil'evich Gatilov
, 
Ekaterina Olegovna Sinegubova 3
Ekaterina Olegovna Sinegubova
, 
Alexandrina S Volobueva 3
Alexandrina S Volobueva
, 
Vladimir Victorovich Zarubaev 3
Vladimir Victorovich Zarubaev
, 
Nariman Faridovich Salakhutdinov 1
Nariman Faridovich Salakhutdinov
10.1016/j.mencom.2022.09.013
Published 2022-09-05
Communication , Volume 32, Issue 5, 609-611
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Yarovaya O. I. et al. Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 609-611.
GOST all authors (up to 50) Copy
Yarovaya O. I., Kovaleva K. S., Borisevich S. S., Rybalova T. V., Gatilov Y. V., Sinegubova E. O., Volobueva A. S., Zarubaev V. V., Salakhutdinov N. F. Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 609-611.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.013
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.013
TI - Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene
T2 - Mendeleev Communications
AU - Yarovaya, Olga Ivanovna
AU - Kovaleva, Kseniya Sergeevna
AU - Borisevich, Sophia Stanislavovna
AU - Rybalova, Tatyana Valeryevna
AU - Gatilov, Yuriy Vasil'evich
AU - Sinegubova, Ekaterina Olegovna
AU - Volobueva, Alexandrina S
AU - Zarubaev, Vladimir Victorovich
AU - Salakhutdinov, Nariman Faridovich
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 609-611
IS - 5
VL - 32
ER -
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@article{2022_Yarovaya,
author = {Olga Ivanovna Yarovaya and Kseniya Sergeevna Kovaleva and Sophia Stanislavovna Borisevich and Tatyana Valeryevna Rybalova and Yuriy Vasil'evich Gatilov and Ekaterina Olegovna Sinegubova and Alexandrina S Volobueva and Vladimir Victorovich Zarubaev and Nariman Faridovich Salakhutdinov},
title = {Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.013},
number = {5},
pages = {609--611},
doi = {10.1016/j.mencom.2022.09.013}
}
MLA
Cite this
MLA Copy
Yarovaya, Olga Ivanovna, et al. “Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 609-611. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.013.

Keywords

acetonitrile
amides
antiviral agents
caryophyllene
humulene
influenza
molecular modeling
Ritter reaction

Abstract

The Ritter reaction of humulene with acetonitrile occurs as the biomimetic process to afford the amide having the skeleton of a natural alcohol. The structures of the amides obtained from humulene and caryophyllene were confirmed by XRD data. The activity of some cage compounds against influenza virus allowed one to suggest the mechanism of antiviral action based on interfering with membrane fusion activity of viral hemagglutinin.

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