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Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity

Nikita Andreevich Frolov 1
Nikita Andreevich Frolov
, 
Vladimir A Smirnov 1, 2
Vladimir A Smirnov
, 
Elena Vladimirovna Detusheva 3
Elena Vladimirovna Detusheva
, 
Anatoly Nikolaevich Vereshchagin 1
Anatoly Nikolaevich Vereshchagin
10.1016/j.mencom.2022.09.012
Published 2022-09-05
Communication , Volume 32, Issue 5, 606-608
3
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Frolov N. A. et al. Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 606-608.
GOST all authors (up to 50) Copy
Frolov N. A., Smirnov V. A., Detusheva E. V., Vereshchagin A. N. Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 606-608.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.012
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.012
TI - Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity
T2 - Mendeleev Communications
AU - Frolov, Nikita Andreevich
AU - Smirnov, Vladimir A
AU - Detusheva, Elena Vladimirovna
AU - Vereshchagin, Anatoly Nikolaevich
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 606-608
IS - 5
VL - 32
ER -
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@article{2022_Frolov,
author = {Nikita Andreevich Frolov and Vladimir A Smirnov and Elena Vladimirovna Detusheva and Anatoly Nikolaevich Vereshchagin},
title = {Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.012},
number = {5},
pages = {606--608},
doi = {10.1016/j.mencom.2022.09.012}
}
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Frolov, Nikita Andreevich, et al. “Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 606-608. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.012.

Keywords

alkylation
antibacterial agents
biocides
biological activity
pyridinium compounds
quaternary bis-ammonium compounds

Abstract

Novel para-substituted bis-pyridinium compounds containing 2,7-dioxynaphthalene spacer were synthesized in two simple steps from the corresponding dihydroxy-naphthalene. The microbiological study on five reference (E. coli ATCC 25922, K. pneumoniae ATCC 70060, S. aureus ATCC 43300, P. aeruginosa ATCC27853, and A. baumannii ATCC 15308) and five clinical (E. coli B-3421/19,K. pneumoniae B-2523/18, S. aureus B-8648, P. aeruginosa B-2099/18 and A. baumannii B-2926/18) bacterial strains showed promising range of antibacterial properties for these biocides, compared to modern sanitizers.

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