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Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands

Van-Ha Nguyen 1
Van-Ha Nguyen
, 
Hien T.T Phung 1
Hien T.T Phung
, 
Dat T Doan 1
Dat T Doan
, 
Thao T Do 2
Thao T Do
10.1016/j.mencom.2022.09.008
Published 2022-09-05
Communication , Volume 32, Issue 5, 594-596
3
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Nguyen V. et al. Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 594-596.
GOST all authors (up to 50) Copy
Nguyen V., Phung H. T., Doan D. T., Do T. T. Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 594-596.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.008
TI - Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands
T2 - Mendeleev Communications
AU - Nguyen, Van-Ha
AU - Phung, Hien T.T
AU - Doan, Dat T
AU - Do, Thao T
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 594-596
IS - 5
VL - 32
ER -
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@article{2022_Nguyen,
author = {Van-Ha Nguyen and Hien T.T Phung and Dat T Doan and Thao T Do},
title = {Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.008},
number = {5},
pages = {594--596},
doi = {10.1016/j.mencom.2022.09.008}
}
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Nguyen, Van-Ha, et al. “Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 594-596. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.008.

Keywords

1,2,4-triazolin-5-ylidene ligands
anticancer activities
NMR probe
palladium-NHC
palladium(II) complexes

Abstract

Two novel palladium(ii) complexes, trans-[PdBr2(tz-Mes)2] and trans-[PdBr2(tz-Dipp)2] featuring less explored 1,2,4-triazole-derived N-heterocyclic carbene (tz) have been synthesized. In solution, they exist both as trans-syn and trans-anti rotamers while their syn/anti ratios can be determined by 1H NMR harnessing the built-in aromatic rings as NMR probes. Complex trans-[PdBr2(tz-Mes)2] is highly cytotoxic toward A549, MCF-7, LNCaP and HT-29 cancerous cells.

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