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Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate

Vasily Vladimirovich Spiridonov 1
Vasily Vladimirovich Spiridonov
, 
Kirill Sergeyevich Sadovnikov 1
Kirill Sergeyevich Sadovnikov
, 
Dmitry Alekseevich Vasilenko 1
Dmitry Alekseevich Vasilenko
,  , 
Alina Radikovna Lukmanova 2
Alina Radikovna Lukmanova
, 
Alina Alexandrovna Markova 3, 4
Alina Alexandrovna Markova
, 
Anna Valer'evna Shibaeva 3
Anna Valer'evna Shibaeva
, 
Anastasia Vladimirovna Bolshakova 1
Anastasia Vladimirovna Bolshakova
, 
Sergey Sergeevich Karlov 1
Sergey Sergeevich Karlov
, 
Elena Borisovna Averina 1
Elena Borisovna Averina
, 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
10.1016/j.mencom.2022.09.007
Published 2022-09-05
Communication , Volume 32, Issue 5, 591-593
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Spiridonov V. V. et al. Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 591-593.
GOST all authors (up to 50) Copy
Spiridonov V. V., Sadovnikov K. S., Vasilenko D. A., Sedenkova K. N., Lukmanova A. R., Markova A. A., Shibaeva A. V., Bolshakova A. V., Karlov S. S., Averina E. B., Yaroslavov A. A. Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate // Mendeleev Communications. 2022. Vol. 32. No. 5. pp. 591-593.
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TY - JOUR
DO - 10.1016/j.mencom.2022.09.007
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.007
TI - Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate
T2 - Mendeleev Communications
AU - Spiridonov, Vasily Vladimirovich
AU - Sadovnikov, Kirill Sergeyevich
AU - Vasilenko, Dmitry Alekseevich
AU - Sedenkova, Kseniya N
AU - Lukmanova, Alina Radikovna
AU - Markova, Alina Alexandrovna
AU - Shibaeva, Anna Valer'evna
AU - Bolshakova, Anastasia Vladimirovna
AU - Karlov, Sergey Sergeevich
AU - Averina, Elena Borisovna
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2022
DA - 2022/09/05
PB - Mendeleev Communications
SP - 591-593
IS - 5
VL - 32
ER -
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@article{2022_Spiridonov,
author = {Vasily Vladimirovich Spiridonov and Kirill Sergeyevich Sadovnikov and Dmitry Alekseevich Vasilenko and Kseniya N Sedenkova and Alina Radikovna Lukmanova and Alina Alexandrovna Markova and Anna Valer'evna Shibaeva and Anastasia Vladimirovna Bolshakova and Sergey Sergeevich Karlov and Elena Borisovna Averina and Aleksandr Anatol'evich Yaroslavov},
title = {Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.007},
number = {5},
pages = {591--593},
doi = {10.1016/j.mencom.2022.09.007}
}
MLA
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Spiridonov, Vasily Vladimirovich, et al. “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate.” Mendeleev Communications, vol. 32, no. 5, Sep. 2022, pp. 591-593. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.09.007.

Keywords

4-acylaminoisoxazoles
alginate
anticancer activity
colloidal stability
polysaccharide nanocontainers

Abstract

Water-dispersible complexes of 4-methyl-N-[5-methyl-3-(3,4,5-trimethoxyphenyl)isoxazol-4-yl]benzamide possessing anticancer activity were prepared by its immobilization with biocompatible polymer nanocontainers based on sodium alginate cross-linked with Ca2+ and Mg2+ ions. It was found that this isoxazole derivative retains its structure during immobilization. Colloidal stable nanocontainers filled with this compound exhibit toxicity toward the colon carcinoma (HCT116) tumor cell line.

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