Home / Publications / Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography

Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography

, 
Yuliya Evgenievna Ryzhkova 1
Yuliya Evgenievna Ryzhkova
, 
Varvara Mikhailovna Kalashnikova 1
Varvara Mikhailovna Kalashnikova
, 
Mikhail Petrovich Egorov 1
Mikhail Petrovich Egorov
10.1016/j.mencom.2022.07.036
Published 2022-07-01
Communication , Volume 32, Issue 4, 543-545
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Elinson M. N. et al. Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 543-545.
GOST all authors (up to 50) Copy
Elinson M. N., Ryzhkova Y. E., Kalashnikova V. M., Egorov M. P. Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 543-545.
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TY - JOUR
DO - 10.1016/j.mencom.2022.07.036
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.036
TI - Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography
T2 - Mendeleev Communications
AU - Elinson, Michail Nikolaevich
AU - Ryzhkova, Yuliya Evgenievna
AU - Kalashnikova, Varvara Mikhailovna
AU - Egorov, Mikhail Petrovich
PY - 2022
DA - 2022/07/01
PB - Mendeleev Communications
SP - 543-545
IS - 4
VL - 32
ER -
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@article{2022_Elinson,
author = {Michail Nikolaevich Elinson and Yuliya Evgenievna Ryzhkova and Varvara Mikhailovna Kalashnikova and Mikhail Petrovich Egorov},
title = {Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.036},
number = {4},
pages = {543--545},
doi = {10.1016/j.mencom.2022.07.036}
}
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Elinson, Michail Nikolaevich, et al. “Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography.” Mendeleev Communications, vol. 32, no. 4, Jul. 2022, pp. 543-545. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.036.

Keywords

13-diketone
3-hydroxyindolin-2-one
aldol reaction
isatin
noncatalytic
on water

Abstract

Noncatalytic on water aldol transformation of isatins and cyclic 1,3-diketones results in substituted 3-hydroxy-3-(2-hydroxy-6-oxocyclohex-1-en-1-yl)indolin-2-ones in 87–98% yields. Optimized conditions have been found and a mechanistic rationale for the reaction has been deduced. The new efficient and facile process represents a convenient way to compounds with the 3-hydroxyindolin-2-one and 3-hydroxycyclohex-2-en-1-one moieties.

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