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Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip

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Grigorev G. V. et al. Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 504-506.
GOST all authors (up to 50) Copy
Grigorev G. V., Lebedev A. V., Wang X., Qian X., Maksimov G. V., Parshina E. U., Lin L. Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 504-506.
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TY - JOUR
DO - 10.1016/j.mencom.2022.07.024
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.024
TI - Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip
T2 - Mendeleev Communications
AU - Grigorev, Georgii V
AU - Lebedev, Alexander Vladimirovich
AU - Wang, Xiaohao
AU - Qian, Xiang
AU - Maksimov, Georgiy Vladimirovich
AU - Parshina, Evgenia Ur'evna
AU - Lin, Liwei
PY - 2022
DA - 2022/07/01
PB - Mendeleev Communications
SP - 504-506
IS - 4
VL - 32
ER -
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@article{2022_Grigorev,
author = {Georgii V Grigorev and Alexander Vladimirovich Lebedev and Xiaohao Wang and Xiang Qian and Georgiy Vladimirovich Maksimov and Evgenia Ur'evna Parshina and Liwei Lin},
title = {Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.024},
number = {4},
pages = {504--506},
doi = {10.1016/j.mencom.2022.07.024}
}
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Grigorev, Georgii V., et al. “Hemoglobin conformation detection by Raman spectroscopy on single human red blood cells captured in a microfluidic chip.” Mendeleev Communications, vol. 32, no. 4, Jul. 2022, pp. 504-506. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.024.

Keywords

conformation
erythrocyte
hemoglobin
microfluidics
Raman spectroscopy
RBC

Abstract

The Raman spectrum of a single erythrocyte captured by a microfluidic chip was recorded to determine the conformation of hemoglobin under conditions similar to the hemodynamics of a blood vessel. Amplitude changes in the Raman spectrum at 1355, 1375, 1552, 1620, 1585 and 1637 cm−1 reflect changes in pO2 due to O2 binding to hemoglobin heme.

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