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Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

Mikhail Yur'evich Krasavin 1
Mikhail Yur'evich Krasavin
, 
Anton Andreevich Shetnev 2
Anton Andreevich Shetnev
, 
Valeria Anatol'evna Panova 2
Valeria Anatol'evna Panova
, 
Sergey Aleksandrovich Ivanovskii 2
Sergey Aleksandrovich Ivanovskii
, 
Stanislav Alekseevich Kalinin 1
Stanislav Alekseevich Kalinin
, 
Tatiana Ivanovna Vinogradova 3
Tatiana Ivanovna Vinogradova
, 
Vladimir Vladimirovich Sharoyko 1
Vladimir Vladimirovich Sharoyko
, 
Piotr Yablonsky 3
Piotr Yablonsky
10.1016/j.mencom.2022.07.008
Published 2022-07-01
Communication , Volume 32, Issue 4, 452-453
6
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Krasavin M. Y. et al. Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 452-453.
GOST all authors (up to 50) Copy
Krasavin M. Y., Shetnev A. A., Panova V. A., Ivanovskii S. A., Kalinin S. A., Vinogradova T. I., Sharoyko V. V., Yablonsky P. Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 452-453.
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TY - JOUR
DO - 10.1016/j.mencom.2022.07.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.008
TI - Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents
T2 - Mendeleev Communications
AU - Krasavin, Mikhail Yur'evich
AU - Shetnev, Anton Andreevich
AU - Panova, Valeria Anatol'evna
AU - Ivanovskii, Sergey Aleksandrovich
AU - Kalinin, Stanislav Alekseevich
AU - Vinogradova, Tatiana Ivanovna
AU - Sharoyko, Vladimir Vladimirovich
AU - Yablonsky, Piotr
PY - 2022
DA - 2022/07/01
PB - Mendeleev Communications
SP - 452-453
IS - 4
VL - 32
ER -
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@article{2022_Krasavin,
author = {Mikhail Yur'evich Krasavin and Anton Andreevich Shetnev and Valeria Anatol'evna Panova and Sergey Aleksandrovich Ivanovskii and Stanislav Alekseevich Kalinin and Tatiana Ivanovna Vinogradova and Vladimir Vladimirovich Sharoyko and Piotr Yablonsky},
title = {Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.008},
number = {4},
pages = {452--453},
doi = {10.1016/j.mencom.2022.07.008}
}
MLA
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Krasavin, Mikhail Yur'evich, et al. “Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents.” Mendeleev Communications, vol. 32, no. 4, Jul. 2022, pp. 452-453. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.07.008.

Keywords

124-oxadiazoles
amidoximes
antibacterial assay
antimycobacterial assay
Cell viability
direct bond
MTT assay
nitrofurans
olefin linker

Abstract

New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.

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