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Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core

Samvel N Sirakanyan 1
Samvel N Sirakanyan
, 
Elmira K Hakobyan 1
Elmira K Hakobyan
, 
Domenico Spinelli 2
Domenico Spinelli
, 
Athina Geronikaki 3
Athina Geronikaki
, 
Victor Georgievich Kartsev 4
Victor Georgievich Kartsev
, 
Hasmik A Yegoryan 1
Hasmik A Yegoryan
, 
Anush A Hovakimyan 1
Anush A Hovakimyan
2 Dipartimento di Chimica ''G. Ciamician'', Universita degli Studi di Bologna, Bologna, Italy
4 'InterBioScreen Ltd.', Chernogolovka, Moscow Region, Russian Federation
10.1016/j.mencom.2022.05.034
Published 2022-04-29
Communication , Volume 32, Issue 3, 393-394
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Sirakanyan S. N. et al. Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core // Mendeleev Communications. 2022. Vol. 32. No. 3. pp. 393-394.
GOST all authors (up to 50) Copy
Sirakanyan S. N., Hakobyan E. K., Spinelli D., Geronikaki A., Kartsev V. G., Yegoryan H. A., Hovakimyan A. A. Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core // Mendeleev Communications. 2022. Vol. 32. No. 3. pp. 393-394.
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TY - JOUR
DO - 10.1016/j.mencom.2022.05.034
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.034
TI - Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core
T2 - Mendeleev Communications
AU - Sirakanyan, Samvel N
AU - Hakobyan, Elmira K
AU - Spinelli, Domenico
AU - Geronikaki, Athina
AU - Kartsev, Victor Georgievich
AU - Yegoryan, Hasmik A
AU - Hovakimyan, Anush A
PY - 2022
DA - 2022/04/29
PB - Mendeleev Communications
SP - 393-394
IS - 3
VL - 32
ER -
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@article{2022_Sirakanyan,
author = {Samvel N Sirakanyan and Elmira K Hakobyan and Domenico Spinelli and Athina Geronikaki and Victor Georgievich Kartsev and Hasmik A Yegoryan and Anush A Hovakimyan},
title = {Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.034},
number = {3},
pages = {393--394},
doi = {10.1016/j.mencom.2022.05.034}
}
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Cite this
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Sirakanyan, Samvel N., et al. “Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core.” Mendeleev Communications, vol. 32, no. 3, Apr. 2022, pp. 393-394. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.034.

Keywords

2,7-naphthyridines
acetylacetone
heterocyclization
hydrazine
pyrazolo[3,4-c][1,2,4]triazolo[3,4-a]-2,7- naphthyridines
pyrazolo[3,4-c]tetrazolo[5,1-a]-2,7-naphthyridine
pyrimido[1' 2':1,5]pyrazolo[3,4-c]-2,7-naphthyridine

Abstract

Efficient syntheses of new heterocyclic systems comprising pyrimido[1',2':1,5]pyrazolo[3,4-c]-2,7-naphthyridine, pyrazolo[3,4-c][1,2,4]triazolo[3,4-a]-2,7-naphthyridine and pyrazolo[3,4-c]tetrazolo[5,1-a]-2,7-naphthyridine cores were performed in two simple steps. In the first step, pyrazole ring was fused at the 2-chloro-3-cyanopyridine moiety by treatment with hydrazine. In the second step, pyrimidine part was fused at the thus formed 3-aminopyrazole moiety by heterocyclization with acetylacetone.

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