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Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates

Anna Alexandrovna Druzina 1
Anna Alexandrovna Druzina
, 
Nadezhda Vadimovna Dudarova 1
Nadezhda Vadimovna Dudarova
, 
Olga Borisovna Zhidkova 1
Olga Borisovna Zhidkova
, 
Ivan Alekseevich Razumov 2
Ivan Alekseevich Razumov
, 
Olga Igorevna Solovieva 2
Olga Igorevna Solovieva
, 
Vladimir Vladimirovich Kanygin 3
Vladimir Vladimirovich Kanygin
, 
Vladimir Iosifovich Bregadze 1
Vladimir Iosifovich Bregadze
10.1016/j.mencom.2022.05.021
Published 2022-04-29
Communication , Volume 32, Issue 3, 354-356
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Druzina A. A. et al. Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates // Mendeleev Communications. 2022. Vol. 32. No. 3. pp. 354-356.
GOST all authors (up to 50) Copy
Druzina A. A., Dudarova N. V., Zhidkova O. B., Razumov I. A., Solovieva O. I., Kanygin V. V., Bregadze V. I. Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates // Mendeleev Communications. 2022. Vol. 32. No. 3. pp. 354-356.
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TY - JOUR
DO - 10.1016/j.mencom.2022.05.021
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.021
TI - Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates
T2 - Mendeleev Communications
AU - Druzina, Anna Alexandrovna
AU - Dudarova, Nadezhda Vadimovna
AU - Zhidkova, Olga Borisovna
AU - Razumov, Ivan Alekseevich
AU - Solovieva, Olga Igorevna
AU - Kanygin, Vladimir Vladimirovich
AU - Bregadze, Vladimir Iosifovich
PY - 2022
DA - 2022/04/29
PB - Mendeleev Communications
SP - 354-356
IS - 3
VL - 32
ER -
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@article{2022_Druzina,
author = {Anna Alexandrovna Druzina and Nadezhda Vadimovna Dudarova and Olga Borisovna Zhidkova and Ivan Alekseevich Razumov and Olga Igorevna Solovieva and Vladimir Vladimirovich Kanygin and Vladimir Iosifovich Bregadze},
title = {Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Apr},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.021},
number = {3},
pages = {354--356},
doi = {10.1016/j.mencom.2022.05.021}
}
MLA
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MLA Copy
Druzina, Anna Alexandrovna, et al. “Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates.” Mendeleev Communications, vol. 32, no. 3, Apr. 2022, pp. 354-356. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.05.021.

Keywords

boron cage
boron neutron capture therapy
cancer
cholesterol
cobalt bis(dicarbollide)
cytotoxicity
human glioblastoma U-87 MG
lipids
liposomes

Abstract

The novel conjugates of cholesterol with cobalt – bis(dicarbollide) were synthesized by the ring-opening reactions of the cyclic oxonium derivatives of [3,3′-Co(C2B9H11)2]– with the OH group of cholesterol 2-hydroxyethyl ether. The compounds obtained were tested for toxicity to glioblastoma U-87 MG cells and human embryo fibroblasts FECH-15 cells

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