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Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones

Victor Anatol'evich Egorov 1
Victor Anatol'evich Egorov
, 
Lidiya Semionovna Khasanova 1
Lidiya Semionovna Khasanova
, 
Fanuza Arslanovna Gimalova 1
Fanuza Arslanovna Gimalova
, 
Alexander Nikolaevich Lobov 1
Alexander Nikolaevich Lobov
, 
Diana Valievna Ishmetova 2
Diana Valievna Ishmetova
, 
Vener Absatarovich Vakhitov 2
Vener Absatarovich Vakhitov
, 
Mansur Sagar'yarovich Miftakhov 1
Mansur Sagar'yarovich Miftakhov
10.1016/j.mencom.2022.03.010
Published 2022-03-06
Communication , Volume 32, Issue 2, 183-185
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Egorov V. A. et al. Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 183-185.
GOST all authors (up to 50) Copy
Egorov V. A., Khasanova L. S., Gimalova F. A., Lobov A. N., Ishmetova D. V., Vakhitov V. A., Miftakhov M. S. Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 183-185.
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TY - JOUR
DO - 10.1016/j.mencom.2022.03.010
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.010
TI - Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones
T2 - Mendeleev Communications
AU - Egorov, Victor Anatol'evich
AU - Khasanova, Lidiya Semionovna
AU - Gimalova, Fanuza Arslanovna
AU - Lobov, Alexander Nikolaevich
AU - Ishmetova, Diana Valievna
AU - Vakhitov, Vener Absatarovich
AU - Miftakhov, Mansur Sagar'yarovich
PY - 2022
DA - 2022/03/06
PB - Mendeleev Communications
SP - 183-185
IS - 2
VL - 32
ER -
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@article{2022_Egorov,
author = {Victor Anatol'evich Egorov and Lidiya Semionovna Khasanova and Fanuza Arslanovna Gimalova and Alexander Nikolaevich Lobov and Diana Valievna Ishmetova and Vener Absatarovich Vakhitov and Mansur Sagar'yarovich Miftakhov},
title = {Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.010},
number = {2},
pages = {183--185},
doi = {10.1016/j.mencom.2022.03.010}
}
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Egorov, Victor Anatol'evich, et al. “Cytotoxicity of novel cross-conjugated arylated cyclopentene-1,3-diones.” Mendeleev Communications, vol. 32, no. 2, Mar. 2022, pp. 183-185. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.010.

Keywords

3-diones
aldehydes
cross-conjugated cyclopentene-1
cyclopentenones
cytotoxicity
Friedel–Crafts reaction
ketals
Knoevenagel condensation
organochlorine compounds
Suzuki–Miyaura reaction

Abstract

Novel 2,4-dichloro-5-phenylcyclopent-4-ene-1,3-dione and 5-aryl-4-chlorocyclopent-4-ene-1,3-dione were synthesized by the Suzuki–Miyaura or Friedel–Crafts reactions of the di- and trichlorocyclopentenone monoketals and subsequent hydrolysis of the ketal function. Condensation of these diones with (hetero)aromatic aldehydes afforded multifunctional 1,3-cyclopentenediones that showed anticancer activity.Keywords: organochlorine compounds, cyclopentenones, ketals, Suzuki–Miyaura reaction, Friedel–Crafts reaction, Knoevenagel condensation, aldehydes, cross-conjugated cyclopentene-1,3-diones, cytotoxicity.

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