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Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity

Regina Radievna Khairullina 1
Regina Radievna Khairullina
, 
Lilya Useinovna Dzhemileva 1
Lilya Useinovna Dzhemileva
, 
Vladimir Anatol'evich D'yakonov 1
Vladimir Anatol'evich D'yakonov
, 
Askhat Gabdrakhmanovich Ibragimov 1
Askhat Gabdrakhmanovich Ibragimov
, 
10.1016/j.mencom.2022.03.008
Published 2022-03-06
Communication , Volume 32, Issue 2, 178-179
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Khairullina R. R. et al. Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 178-179.
GOST all authors (up to 50) Copy
Khairullina R. R., Dzhemileva L. U., D'yakonov V. A., Ibragimov A. G., Dzhemilev U. M. Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 178-179.
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TY - JOUR
DO - 10.1016/j.mencom.2022.03.008
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.008
TI - Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity
T2 - Mendeleev Communications
AU - Khairullina, Regina Radievna
AU - Dzhemileva, Lilya Useinovna
AU - D'yakonov, Vladimir Anatol'evich
AU - Ibragimov, Askhat Gabdrakhmanovich
AU - Dzhemilev, Usein Memetovich
PY - 2022
DA - 2022/03/06
PB - Mendeleev Communications
SP - 178-179
IS - 2
VL - 32
ER -
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@article{2022_Khairullina,
author = {Regina Radievna Khairullina and Lilya Useinovna Dzhemileva and Vladimir Anatol'evich D'yakonov and Askhat Gabdrakhmanovich Ibragimov and Usein Memetovich Dzhemilev},
title = {Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.008},
number = {2},
pages = {178--179},
doi = {10.1016/j.mencom.2022.03.008}
}
MLA
Cite this
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Khairullina, Regina Radievna, et al. “Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity.” Mendeleev Communications, vol. 32, no. 2, Mar. 2022, pp. 178-179. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.008.

Keywords

1-Dioxide
1,4,2,6-Dithiadiazinane 1
catalysis
Cyclothiomethylation
cytotoxic activity
Hydrogen sulfide
Samarium compounds
Sodium sulfide
Sulfamide
Ytterbium compounds

Abstract

Cyclothiomethylation of sulfamide using paraformaldehyde or bis(dimethylamino)methane, hydrogen sulfide or its sodium salts catalyzed by rare-earth salts affords 1,4,2,6-dithiadi azinane 1,1-dioxide. The heterocycle was found to exhibit a pronounced cytotoxic effect against suspension tumor cell lines (Jurkat, HL60, K562, and U937).

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