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Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells

Nikolay Alekseevich Zefirov 1
Nikolay Alekseevich Zefirov
, 
Apollonia Glassl 2
Apollonia Glassl
, 
Eugene V Radchenko 1
Eugene V Radchenko
, 
Anastasia N Borovik 1
Anastasia N Borovik
, 
Vladislav Vitalyevich Stanishevskiy 1
Vladislav Vitalyevich Stanishevskiy
,  , 
Sergei A Kuznetsov 2
Sergei A Kuznetsov
, 
Ol'ga Nikolaevna Zefirova 1
Ol'ga Nikolaevna Zefirova
10.1016/j.mencom.2022.03.006
Published 2022-03-06
Communication , Volume 32, Issue 2, 173-175
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Zefirov N. A. et al. Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 173-175.
GOST all authors (up to 50) Copy
Zefirov N. A., Glassl A., Radchenko E. V., Borovik A. N., Stanishevskiy V. V., Milaeva E. R., Kuznetsov S. A., Zefirova O. N. Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells // Mendeleev Communications. 2022. Vol. 32. No. 2. pp. 173-175.
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TY - JOUR
DO - 10.1016/j.mencom.2022.03.006
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.006
TI - Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells
T2 - Mendeleev Communications
AU - Zefirov, Nikolay Alekseevich
AU - Glassl, Apollonia
AU - Radchenko, Eugene V
AU - Borovik, Anastasia N
AU - Stanishevskiy, Vladislav Vitalyevich
AU - Milaeva, Elena Rudol'fovna
AU - Kuznetsov, Sergei A
AU - Zefirova, Ol'ga Nikolaevna
PY - 2022
DA - 2022/03/06
PB - Mendeleev Communications
SP - 173-175
IS - 2
VL - 32
ER -
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@article{2022_Zefirov,
author = {Nikolay Alekseevich Zefirov and Apollonia Glassl and Eugene V Radchenko and Anastasia N Borovik and Vladislav Vitalyevich Stanishevskiy and Elena Rudol'fovna Milaeva and Sergei A Kuznetsov and Ol'ga Nikolaevna Zefirova},
title = {Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Mar},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.006},
number = {2},
pages = {173--175},
doi = {10.1016/j.mencom.2022.03.006}
}
MLA
Cite this
MLA Copy
Zefirov, Nikolay Alekseevich, et al. “Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells.” Mendeleev Communications, vol. 32, no. 2, Mar. 2022, pp. 173-175. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.03.006.

Keywords

alicyclic compounds
Bridged moieties
esters
Human lung carcinoma A549
Immunofluorescence microscopy
Microtubules
molecular dynamics
Podophyllotoxin
tubulin

Abstract

Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C4-esters at different concentrations gave evidence that the ‘curling’ of microtubules occurred at one of the first steps of their depolymerisation. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin.

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