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A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins

Maxim Evgenievich Kukushkin 1, 2
Maxim Evgenievich Kukushkin
, 
Nikita Aleksandrovich Karpov 1
Nikita Aleksandrovich Karpov
, 
Dmitry Evgenievich Shybanov 1
Dmitry Evgenievich Shybanov
, 
Nikolai Vasil'evich Zyk 1
Nikolai Vasil'evich Zyk
, 
10.1016/j.mencom.2022.01.041
Published 2022-01-03
Communication , Volume 32, Issue 1, 126-128
11
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Kukushkin M. E. et al. A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 126-128.
GOST all authors (up to 50) Copy
Kukushkin M. E., Karpov N. A., Shybanov D. E., Zyk N. V., Beloglazkina E. K. A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 126-128.
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TY - JOUR
DO - 10.1016/j.mencom.2022.01.041
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.041
TI - A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins
T2 - Mendeleev Communications
AU - Kukushkin, Maxim Evgenievich
AU - Karpov, Nikita Aleksandrovich
AU - Shybanov, Dmitry Evgenievich
AU - Zyk, Nikolai Vasil'evich
AU - Beloglazkina, Elena Kimovna
PY - 2022
DA - 2022/01/03
PB - Mendeleev Communications
SP - 126-128
IS - 1
VL - 32
ER -
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@article{2022_Kukushkin,
author = {Maxim Evgenievich Kukushkin and Nikita Aleksandrovich Karpov and Dmitry Evgenievich Shybanov and Nikolai Vasil'evich Zyk and Elena Kimovna Beloglazkina},
title = {A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.041},
number = {1},
pages = {126--128},
doi = {10.1016/j.mencom.2022.01.041}
}
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Kukushkin, Maxim Evgenievich, et al. “A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins.” Mendeleev Communications, vol. 32, no. 1, Jan. 2022, pp. 126-128. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.041.

Keywords

2-thiohydantoins
amino acids
exocyclic C=C bond
heterocyclization
isothiocyanates

Abstract

3-Aryl-5-methylidene-2-thiohydantoins were constructed in one-pot reaction of aryl isothiocyanates and 3-morpholino- alanine in alkaline medium with the subsequent treatment with boiling hydrochloric acid.

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