Keywords
o-diarylazoles
antimitotic activity
isoxazoles
microtubule destabilization
nitrostilbenes
pyrazoles
pyrroles
sea urchin embryo
triazoles
Abstract
Monomethoxy substituted o-diarylazoles with isoxazole, triazole, pyrazole, or pyrrole linkers were synthesized and evaluated for antimitotic antitubulin activity in a sea urchin embryo model. Structure–activity relationship study revealed that only isoxazole heterocycle together with the unsubstituted phenyl ring next to the heteroatom endowed the molecule with appropriate configuration to exhibit antiproliferative effect by microtubule destabilizing mode of action.
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