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New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro

Natalya Vital'evna Fadeeva 1
Natalya Vital'evna Fadeeva
Julia Alekseevna Skripets 2
Julia Alekseevna Skripets
Vladislav Mikhailovich Ignatiev 1, 2
Vladislav Mikhailovich Ignatiev
Irina Igorevna Faingold 1
Irina Igorevna Faingold
Darya Aleksandrovna Poletaeva 1
Darya Aleksandrovna Poletaeva
Raisa Alekseevna Kotelnikova 1
Raisa Alekseevna Kotelnikova
Published 2022-01-03
CommunicationVolume 32, Issue 1, 117-119
9
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Kurmaz S. V. et al. New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 117-119.
GOST all authors (up to 50) Copy
Kurmaz S. V., Fadeeva N. V., Skripets J. A., Komendant R. I., Ignatiev V. M., Emelyanova N. S., Soldatova J. V., Faingold I. I., Poletaeva D. A., Kotelnikova R. A. New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 117-119.
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TY - JOUR
DO - 10.1016/j.mencom.2022.01.038
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.038
TI - New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro
T2 - Mendeleev Communications
AU - Kurmaz, Svetlana Viktorovna
AU - Fadeeva, Natalya Vital'evna
AU - Skripets, Julia Alekseevna
AU - Komendant, Roman Igorevich
AU - Ignatiev, Vladislav Mikhailovich
AU - Emelyanova, Nina Sergeevna
AU - Soldatova, Julia Valerievna
AU - Faingold, Irina Igorevna
AU - Poletaeva, Darya Aleksandrovna
AU - Kotelnikova, Raisa Alekseevna
PY - 2022
DA - 2022/01/03
PB - Mendeleev Communications
SP - 117-119
IS - 1
VL - 32
ER -
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@article{2022_Kurmaz,
author = {Svetlana Viktorovna Kurmaz and Natalya Vital'evna Fadeeva and Julia Alekseevna Skripets and Roman Igorevich Komendant and Vladislav Mikhailovich Ignatiev and Nina Sergeevna Emelyanova and Julia Valerievna Soldatova and Irina Igorevna Faingold and Darya Aleksandrovna Poletaeva and Raisa Alekseevna Kotelnikova},
title = {New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.038},
number = {1},
pages = {117--119},
doi = {10.1016/j.mencom.2022.01.038}
}
MLA
Cite this
MLA Copy
Kurmaz, Svetlana Viktorovna, et al. “New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro.” Mendeleev Communications, vol. 32, no. 1, Jan. 2022, pp. 117-119. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.038.

Keywords

N-vinylpyrrolidone
amphiphilic copolymer
antioxidant activity
encapsulation
triethylene glycol dimethacrylate
α-tocopherol

Abstract

Water-soluble forms of α-tocopherol (vitamin E) possessing antioxidant activity in vitro were obtained by encapsulating in N-vinylpyrrolidone with triethylene glycol dimethacrylate polymer particles and were characterized by various physicochemical methods. Quantum-chemical modeling of a structure of α-tocopherol with the copolymer moiety and its theoretical absorption spectra modeling were carried out.

References

1.
Vitamin E-based nanomedicines for anti-cancer drug delivery
Duhem N., Danhier F., Préat V.
Journal of Controlled Release, 2014
2.
10.1016/j.mencom.2022.01.038_b0010
Halliwell
Free Radicals in Biology and Medicine, 2015
3.
10.1016/j.mencom.2022.01.038_b0015
Poon
Acc. Chem. Res., 1996
5.
Yu. N. Schanin, V. Yu. Schanin and E. V. Zinovyev, Antioksidantnaya terapiya v klinicheskoi praktike (Antioxidant Therapy in Clinical Practice), ELBI-SPb, St. Petersburg, 2003 (in Russian).
6.
Efficacy of water-soluble vitamin E in the treatment of vitamin E malabsorption in short-bowel syndrome
Traber M.G., Schiano T.D., Steephen A.C., Kayden H.J., Shike M.
American Journal of Clinical Nutrition, 1994
7.
Alpha‐tocopherol microspheres with cross‐linked and acetylated inulin and their release profile in a hydrophilic model
García P., Vega J., Jimenez P., Santos J., Robert P.
European Journal of Lipid Science and Technology, 2013
9.
Nanoparticulates as Drug Carriers, ed. V. P. Torchilin, Imperial College Press, London, 2006.
10.
Amphiphilic block copolymer micelles for nanoscale drug delivery
Kwon G.S., Forrest M.L.
Drug Development Research, 2006
12.
G. S. Kwon and M. L. Forrest, US Patent 8173167:B2, 2012.
13.
10.1016/j.mencom.2022.01.038_b0065
Tabandeh
Iran. J. Pharm. Res., 2013
18.
Kurmaz S.V., Fadeeva N.V., Fedorov B.S., Kozub G.I., Emel’yanova N.S., Kurmaz V.A., Manzhos R.A., Balakina A.A., Terentyev A.A.
Mendeleev Communications, 2020
19.
Polymer nanoparticles of N-vinylpyrrolidone loaded with an organic aminonitroxyl platinum (iv) complex. Characterization and investigation of their in vitro cytotoxicity
Kurmaz S.V., Sen’ V.D., Kulikov A.V., Konev D.V., Kurmaz V.A., Balakina A.A., Terent’ev A.A.
Russian Chemical Bulletin, 2019
21.
Structure and State of Water in Branched N-Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound
Kurmaz S.V., Fadeeva N.V., Ignat’ev V.M., Kurmaz V.A., Kurochkin S.A., Emel’yanova N.S.
Molecules, 2020
22.
O. V. Checheta, E. F. Safonova and A. I. Slivkin, Vestnik VGU, Ser. Khim., Biol., Farmatsiya, 2010, no. 2, 164 (in Russian).
23.
10.1016/j.mencom.2022.01.038_b0115
Connors
Binding Constants: The Measurement of Molecular Complex Stability, 1987
24.
Structure and vibrational spectroscopic study of alpha-tocopherol
Singh G., Sachdeva R., Rai B., Saini G.S.
Journal of Molecular Structure, 2017