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19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols

,  , 
Elizaveta Konstantinovna Melnikova 1, 2
Elizaveta Konstantinovna Melnikova
, 
Sergey Konstantinovich Moiseev 1
Sergey Konstantinovich Moiseev
10.1016/j.mencom.2022.01.031
Published 2022-01-03
Communication , Volume 32, Issue 1, 97-99
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Zelentsova M. V. et al. 19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 97-99.
GOST all authors (up to 50) Copy
Zelentsova M. V., Sandulenko I. V., Melnikova E. K., Moiseev S. K. 19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 97-99.
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TY - JOUR
DO - 10.1016/j.mencom.2022.01.031
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.031
TI - 19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols
T2 - Mendeleev Communications
AU - Zelentsova, Maria Valeryevna
AU - Sandulenko, Irina Vladimirovna
AU - Melnikova, Elizaveta Konstantinovna
AU - Moiseev, Sergey Konstantinovich
PY - 2022
DA - 2022/01/03
PB - Mendeleev Communications
SP - 97-99
IS - 1
VL - 32
ER -
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@article{2022_Zelentsova,
author = {Maria Valeryevna Zelentsova and Irina Vladimirovna Sandulenko and Elizaveta Konstantinovna Melnikova and Sergey Konstantinovich Moiseev},
title = {19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {Mendeleev Communications},
month = {Jan},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.031},
number = {1},
pages = {97--99},
doi = {10.1016/j.mencom.2022.01.031}
}
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Zelentsova, Maria Valeryevna, et al. “19F NMR determination of the C20 absolute configuration of C21-fluorinated arylthevinols.” Mendeleev Communications, vol. 32, no. 1, Jan. 2022, pp. 97-99. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2022.01.031.

Keywords

19F NMR
absolute configuration
alkaloids
Grignard reaction
organofluorine compounds
orvinols
thevinols
thevinone

Abstract

21,21,21-Trifluoro(aryl)thevinols were synthesized by the reaction of 21,21,21-trifluorothevinone with aryl Grignard reagents. The absolute configuration at C20 atom in these CF3-substituted alcohols can be easily determined by one-dimensional 19F NMR spectroscopy that was verified by X-ray diffraction studies.

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