Home / Publications / Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor

Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor

Maria Andreevna Merkulova 1
Maria Andreevna Merkulova
, 
Nadezhda Sergeevna Osipova 1
Nadezhda Sergeevna Osipova
, 
Olga Olegovna Maksimenko 1
Olga Olegovna Maksimenko
,  , 
Svetlana Èmmanuilovna Gelperina 1
Svetlana Èmmanuilovna Gelperina
10.1016/j.mencom.2021.11.044
Published 2021-11-08
Communication , Volume 31, Issue 6, 899-901
1
Share
Cite this
GOST
 | 
Cite this
GOST Copy
Merkulova M. A. et al. Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 899-901.
GOST all authors (up to 50) Copy
Merkulova M. A., Osipova N. S., Maksimenko O. O., Gordienko M. G., Gelperina S. È. Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 899-901.
RIS
 | 
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2021.11.044
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.044
TI - Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor
T2 - Mendeleev Communications
AU - Merkulova, Maria Andreevna
AU - Osipova, Nadezhda Sergeevna
AU - Maksimenko, Olga Olegovna
AU - Gordienko, Maria Gennadievna
AU - Gelperina, Svetlana Èmmanuilovna
PY - 2021
DA - 2021/11/08
PB - Mendeleev Communications
SP - 899-901
IS - 6
VL - 31
ER -
BibTex
 | 
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Merkulova,
author = {Maria Andreevna Merkulova and Nadezhda Sergeevna Osipova and Olga Olegovna Maksimenko and Maria Gennadievna Gordienko and Svetlana Èmmanuilovna Gelperina},
title = {Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.044},
number = {6},
pages = {899--901},
doi = {10.1016/j.mencom.2021.11.044}
}
MLA
Cite this
MLA Copy
Merkulova, Maria Andreevna, et al. “Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor.” Mendeleev Communications, vol. 31, no. 6, Nov. 2021, pp. 899-901. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.044.

Keywords

drug delivery systems
emulsification–evaporation method
interfacial tension
microfluidics
poly(lactide-co-glycolide) nanoparticles

Abstract

The production of polymer nanoparticles with a narrow size distribution on standard T- and X-configuration microfluidic chips with a channel size of 100 μm has been achieved. Introducing ethanol into the aqueous phase in 1:9 ratio (v/v) allowed one to reduce the surface tension of the contacting phases and obtain nanoparticles in the range of 100–150 nm. This makes our approach promising for development of nanoscale drug delivery systems.

References

1.
Recent Trends in Clinical Trials Related to Carrier-Based Drugs
Tagami T., Ozeki T.
Journal of Pharmaceutical Sciences, 2017
2.
Cells Involved in the Capture of Nanoparticles in Hematopoietic Organs
Gibaud S., Demoy M., Andreux J.P., Weingarten C., Gouritin B., Couvreur P.
Journal of Pharmaceutical Sciences, 2002
4.
Oshchepkov M.S., Semyonkin A.S., Menkov A.O., Melnikov P.A., Valikhov M.P., Solovieva I.N., Tkachenko S.V., Malinowskaya J.A.
Mendeleev Communications, 2020
7.
10.1016/j.mencom.2021.11.044_b0035
Liu
Lab Chip, 1856
9.
Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures
Ragelle H., Danhier F., Préat V., Langer R., Anderson D.G.
Expert Opinion on Drug Delivery, 2016
10.
PLGA-based nanoparticles: A new paradigm in biomedical applications
Sharma S., Parmar A., Kori S., Sandhir R.
TrAC - Trends in Analytical Chemistry, 2016
11.
Chernysheva Y.V., Babak V.G., Kildeeva N.R., Boury F., Benoit J.P., Ubrich N., Maincent P.
Mendeleev Communications, 2003
12.
Synthesis and characterization of PLGA nanoparticles
Astete C.E., Sabliov C.M.
Journal of Biomaterials Science, Polymer Edition, 2006
13.
I. V. Shulyak and E. I. Grushova, Trudy BGTU. Seriya IV (Proceedings of BSTU. Series IV), Khimiya, tekhnologiya organicheskikh veshchestv i biotekhnologiya, 2009, 92 (in Russian).
15.
Microfluidics: A focus on improved cancer targeted drug delivery systems
Khan I.U., Serra C.A., Anton N., Vandamme T.
Journal of Controlled Release, 2013
17.
Fabrication and Applications of Microfluidic Devices: A Review
Niculescu A., Chircov C., Bîrcă A.C., Grumezescu A.M.
International Journal of Molecular Sciences, 2021