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Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests

Victoria Vadimovna Abzianidze 1
Victoria Vadimovna Abzianidze
, 
Yulia Victorovna Chelusnova 1
Yulia Victorovna Chelusnova
, 
Georgy Vasil'evich Karakashev 1
Georgy Vasil'evich Karakashev
, 
Dmitrii Mikhaylovich Kochura 1
Dmitrii Mikhaylovich Kochura
, 
Michael Aleksandrovich Leninskii 1
Michael Aleksandrovich Leninskii
, 
Alexander Yur'evich Gorbunov 1
Alexander Yur'evich Gorbunov
, 
Mariya Dmitrievna Shachneva 1
Mariya Dmitrievna Shachneva
, 
Denis Victorovich Krivorotov 1
Denis Victorovich Krivorotov
, 
Anton Igorevich Ukolov 1
Anton Igorevich Ukolov
1 Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
10.1016/j.mencom.2021.11.033
Published 2021-11-08
Communication , Volume 31, Issue 6, 867-868
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Abzianidze V. V. et al. Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 867-868.
GOST all authors (up to 50) Copy
Abzianidze V. V., Chelusnova Y. V., Karakashev G. V., Kochura D. M., Leninskii M. A., Gorbunov A. Y., Shachneva M. D., Krivorotov D. V., Ukolov A. I. Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 867-868.
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TY - JOUR
DO - 10.1016/j.mencom.2021.11.033
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.033
TI - Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests
T2 - Mendeleev Communications
AU - Abzianidze, Victoria Vadimovna
AU - Chelusnova, Yulia Victorovna
AU - Karakashev, Georgy Vasil'evich
AU - Kochura, Dmitrii Mikhaylovich
AU - Leninskii, Michael Aleksandrovich
AU - Gorbunov, Alexander Yur'evich
AU - Shachneva, Mariya Dmitrievna
AU - Krivorotov, Denis Victorovich
AU - Ukolov, Anton Igorevich
PY - 2021
DA - 2021/11/08
PB - Mendeleev Communications
SP - 867-868
IS - 6
VL - 31
ER -
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@article{2021_Abzianidze,
author = {Victoria Vadimovna Abzianidze and Yulia Victorovna Chelusnova and Georgy Vasil'evich Karakashev and Dmitrii Mikhaylovich Kochura and Michael Aleksandrovich Leninskii and Alexander Yur'evich Gorbunov and Mariya Dmitrievna Shachneva and Denis Victorovich Krivorotov and Anton Igorevich Ukolov},
title = {Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.033},
number = {6},
pages = {867--868},
doi = {10.1016/j.mencom.2021.11.033}
}
MLA
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Abzianidze, Victoria Vadimovna, et al. “Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests.” Mendeleev Communications, vol. 31, no. 6, Nov. 2021, pp. 867-868. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.033.

Keywords

collision-induced dissociation
OPCW
peptide synthesis
positive control
qualitative and quantitative analysis
sulfides
sulfur mustard
tripeptides

Abstract

S-[2-(2-Hydroxyethylthio)ethyl]-Cys-Pro-Phe (HETE–CPP) was synthesized in seven steps as a reference compound for the development of a procedure for its quantification in blood plasma in the OPCW biomedical proficiency tests.

References

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Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction, https://www.opcw.org/chemical-weapons-convention.
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Methods of determination of sulfur yperite–DNA adducts
Orlova O.I., Savel’eva E.I., Karakashev G.V.
Journal of Analytical Chemistry, 2017
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O. I. Orlova, G. V. Karakashev, V. I. Shmurak, V. V. Abzianidze and E. I. Saveleva, Vestn. Sankt-Peterburg Univ., Ser. 4: Fiz. Khim., 2017, 4, 313 (in Russian).
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An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard
Koryagina N.L., Shachneva M.D., Ukolov A.I., Savel’eva E.I., Khlebnikova N.S., Radilov A.S.
Journal of Analytical Chemistry, 2018
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Synthesis, Characterization and Mass Spectrometric Analysis of Cysteine and Valine Adducts of Sulphur Mustard
Rao M.K., Sharma M., Raza S.K., Jaiswal D.K.
Phosphorus, Sulfur and Silicon and the Related Elements, 2003