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Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units

Sherif M.H. Sanad 1
Sherif M.H. Sanad
, 
Ahmed E.M. Mekky 1
Ahmed E.M. Mekky
10.1016/j.mencom.2021.11.031
Published 2021-11-08
Communication , Volume 31, Issue 6, 862-864
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Sanad S. M., Mekky A. E. Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 862-864.
GOST all authors (up to 50) Copy
Sanad S. M., Mekky A. E. Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 862-864.
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TY - JOUR
DO - 10.1016/j.mencom.2021.11.031
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.031
TI - Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units
T2 - Mendeleev Communications
AU - Sanad, Sherif M.H.
AU - Mekky, Ahmed E.M.
PY - 2021
DA - 2021/11/08
PB - Mendeleev Communications
SP - 862-864
IS - 6
VL - 31
ER -
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@article{2021_Sanad,
author = {Sherif M.H. Sanad and Ahmed E.M. Mekky},
title = {Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.031},
number = {6},
pages = {862--864},
doi = {10.1016/j.mencom.2021.11.031}
}
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Sanad, Sherif M.H., and Ahmed E.M. Mekky. “Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units.” Mendeleev Communications, vol. 31, no. 6, Nov. 2021, pp. 862-864. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.031.

Keywords

[5+1] heterocyclization
in vitro antibacterial screening
cross-imidination
formamidines
microwave-assisted reactions
multicomponent reactions
pyrimidinones
tandem reactions
thieno[2,3-b]pyridines

Abstract

A three-component protocol involving the reaction of 3-aminothieno[2,3-b]pyridine-2-carboxylate, Me2NCH(OMe)2 and heteroaryl (bis)amines in dioxane under microwave irradiation yielded a new series of pyrimidinones. The target hybrids were formed by an initial formamidine formation,Pyrazole-linked pyrimidinones displayed the best antibacterial activity against all the gram-positive and negative strains tested.

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