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pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid

Anton Sergeyevich Popov 1
Anton Sergeyevich Popov
, 
Anna Aleksandrovna Efimova 1
Anna Aleksandrovna Efimova
, 
Alexey Vital'evich Kazantsev 1
Alexey Vital'evich Kazantsev
, 
Dmitry Alexandrovich Erzunov 1
Dmitry Alexandrovich Erzunov
, 
Nikolai Vadimovich Lukashev 1
Nikolai Vadimovich Lukashev
, 
Irina Dmitrievna Grozdova 1
Irina Dmitrievna Grozdova
, 
Nikolay Sergeevich Melik-Nubarov 1
Nikolay Sergeevich Melik-Nubarov
, 
Aleksandr Anatol'evich Yaroslavov 1
Aleksandr Anatol'evich Yaroslavov
10.1016/j.mencom.2021.11.019
Published 2021-11-08
Communication , Volume 31, Issue 6, 827-829
11
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Popov A. S. et al. pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 827-829.
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Popov A. S., Efimova A. A., Kazantsev A. V., Erzunov D. A., Lukashev N. V., Grozdova I. D., Melik-Nubarov N. S., Yaroslavov A. A. pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 827-829.
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TY - JOUR
DO - 10.1016/j.mencom.2021.11.019
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.019
TI - pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid
T2 - Mendeleev Communications
AU - Popov, Anton Sergeyevich
AU - Efimova, Anna Aleksandrovna
AU - Kazantsev, Alexey Vital'evich
AU - Erzunov, Dmitry Alexandrovich
AU - Lukashev, Nikolai Vadimovich
AU - Grozdova, Irina Dmitrievna
AU - Melik-Nubarov, Nikolay Sergeevich
AU - Yaroslavov, Aleksandr Anatol'evich
PY - 2021
DA - 2021/11/08
PB - Mendeleev Communications
SP - 827-829
IS - 6
VL - 31
ER -
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@article{2021_Popov,
author = {Anton Sergeyevich Popov and Anna Aleksandrovna Efimova and Alexey Vital'evich Kazantsev and Dmitry Alexandrovich Erzunov and Nikolai Vadimovich Lukashev and Irina Dmitrievna Grozdova and Nikolay Sergeevich Melik-Nubarov and Aleksandr Anatol'evich Yaroslavov},
title = {pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Nov},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.019},
number = {6},
pages = {827--829},
doi = {10.1016/j.mencom.2021.11.019}
}
MLA
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Popov, Anton Sergeyevich, et al. “pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid.” Mendeleev Communications, vol. 31, no. 6, Nov. 2021, pp. 827-829. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.11.019.

Keywords

controlled drug delivery
cytotoxicity
molecular switch
pH-sensitive liposome
stimulus-sensitive

Abstract

Stimulus-sensitive liposomes have been prepared from zwitterionic dioleoylphosphocholine and ampholytic molecular switches with carboxylic anionic groups and the triazole or isobutylamino cationic ones attached to the opposite ends of the steroid core. When the pH of outer solution was altered from slightly alkaline to slightly acidic, the switches changed their orientation in the liposomal membrane, which induced temporal defects formation and the release of a drug model load. The low-toxic pH-sensitive isobutylamino derivative–dioleoylphosphocholine liposomes demonstrated fast cargo release.

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