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Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading

Ekaterina Sergeevna Dolinina 1
Ekaterina Sergeevna Dolinina
, 
Elizaveta Yuryevna Akimsheva 1
Elizaveta Yuryevna Akimsheva
, 
Elena Vladimirovna Parfenyuk 1
Elena Vladimirovna Parfenyuk
10.1016/j.mencom.2021.09.038
Published 2021-09-08
Communication , Volume 31, Issue 5, 706-708
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Dolinina E. S., Akimsheva E. Y., Parfenyuk E. V. Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 706-708.
GOST all authors (up to 50) Copy
Dolinina E. S., Akimsheva E. Y., Parfenyuk E. V. Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 706-708.
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TY - JOUR
DO - 10.1016/j.mencom.2021.09.038
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.038
TI - Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading
T2 - Mendeleev Communications
AU - Dolinina, Ekaterina Sergeevna
AU - Akimsheva, Elizaveta Yuryevna
AU - Parfenyuk, Elena Vladimirovna
PY - 2021
DA - 2021/09/08
PB - Mendeleev Communications
SP - 706-708
IS - 5
VL - 31
ER -
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@article{2021_Dolinina,
author = {Ekaterina Sergeevna Dolinina and Elizaveta Yuryevna Akimsheva and Elena Vladimirovna Parfenyuk},
title = {Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.038},
number = {5},
pages = {706--708},
doi = {10.1016/j.mencom.2021.09.038}
}
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Dolinina, Ekaterina Sergeevna, et al. “Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading.” Mendeleev Communications, vol. 31, no. 5, Sep. 2021, pp. 706-708. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.038.

Keywords

acyclovir
composites
release kinetics
silica
silica matrix modification

Abstract

Acyclovir release from its composites with unmodified silica at pH 1.6 and 7.4 follows zero order kinetics for two days. Modification of the silica matrix with phenyl groups leads to dramatic decrease in the drug release level at pH 7.4 compared with pH 1.6 as well as to heterogeneous phase state of acyclovir in the phenyl modified composite with high loading of the drug.

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