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New synthetic corticosteroids inhibit Epstein–Barr virus release

Andrei G Malykh 1
Andrei G Malykh
, 
Andrey R Pavlov 1
Andrey R Pavlov
, 
Alexander Vladimirovich Komkov 2
Alexander Vladimirovich Komkov
, 
Yulia Alekseevna Volkova 2
Yulia Alekseevna Volkova
, 
Leonid Gennad'evich Menchikov 2
Leonid Gennad'evich Menchikov
, 
Igor Viktorovich Zavarzin 2
Igor Viktorovich Zavarzin
10.1016/j.mencom.2021.09.025
Published 2021-09-08
Communication , Volume 31, Issue 5, 667-669
6
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Malykh A. G. et al. New synthetic corticosteroids inhibit Epstein–Barr virus release // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 667-669.
GOST all authors (up to 50) Copy
Malykh A. G., Pavlov A. R., Komkov A. V., Volkova Y. A., Menchikov L. G., Zavarzin I. V. New synthetic corticosteroids inhibit Epstein–Barr virus release // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 667-669.
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TY - JOUR
DO - 10.1016/j.mencom.2021.09.025
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.025
TI - New synthetic corticosteroids inhibit Epstein–Barr virus release
T2 - Mendeleev Communications
AU - Malykh, Andrei G
AU - Pavlov, Andrey R
AU - Komkov, Alexander Vladimirovich
AU - Volkova, Yulia Alekseevna
AU - Menchikov, Leonid Gennad'evich
AU - Zavarzin, Igor Viktorovich
PY - 2021
DA - 2021/09/08
PB - Mendeleev Communications
SP - 667-669
IS - 5
VL - 31
ER -
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@article{2021_Malykh,
author = {Andrei G Malykh and Andrey R Pavlov and Alexander Vladimirovich Komkov and Yulia Alekseevna Volkova and Leonid Gennad'evich Menchikov and Igor Viktorovich Zavarzin},
title = {New synthetic corticosteroids inhibit Epstein–Barr virus release},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.025},
number = {5},
pages = {667--669},
doi = {10.1016/j.mencom.2021.09.025}
}
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Malykh, Andrei G., et al. “New synthetic corticosteroids inhibit Epstein–Barr virus release.” Mendeleev Communications, vol. 31, no. 5, Sep. 2021, pp. 667-669. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.025.

Keywords

1,3,4-thiadiazine
androstene
antiviral activity
Epstein–Barr virus
spironolactone
steroids

Abstract

Novel spiroandrostene-17,6'-[1,3,4]thiadiazines obtained by synthesis from 16β,17β-epoxy-17-isopregn-5-en-3β-ol-20-one and N-aryl-2-hydrazino-2-thioxoacetamide efficiently inhibited the release of Epstein–Barr virus from cells carrying the virus in culture. Other studied steroids, such as Spirolactone, Digitonin, Diosgenin, and Hecogenin were inactive. DMSO alone was found to inhibit the virus release, as well, likely, because of changing properties of the cell membranes. The novel steroids, Spironolactone and most analogues display no or low cell toxicity while Digitonin produced a significant toxic effect.

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