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Anticancer activity of novel 3-azaxanthenes

Ludmila Konstantinovna Kibardina 1
Ludmila Konstantinovna Kibardina
, 
Alexey Vladimirovich Trifonov 1
Alexey Vladimirovich Trifonov
, 
Alexey Borisovich Dobrynin 1
Alexey Borisovich Dobrynin
, 
Michael Arkad'evich Pudovik 1
Michael Arkad'evich Pudovik
, 
Alexander Romanovich Burilov 1
Alexander Romanovich Burilov
, 
Alexandra Dmitrievna Voloshina 1
Alexandra Dmitrievna Voloshina
, 
Anna Georgievna Strelnik 1
Anna Georgievna Strelnik
, 
Almir Sabirovich Gazizov 1
Almir Sabirovich Gazizov
10.1016/j.mencom.2021.09.024
Published 2021-09-08
Communication , Volume 31, Issue 5, 664-666
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Kibardina L. K. et al. Anticancer activity of novel 3-azaxanthenes // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 664-666.
GOST all authors (up to 50) Copy
Kibardina L. K., Trifonov A. V., Dobrynin A. B., Pudovik M. A., Burilov A. R., Voloshina A. D., Strelnik A. G., Gazizov A. S. Anticancer activity of novel 3-azaxanthenes // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 664-666.
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TY - JOUR
DO - 10.1016/j.mencom.2021.09.024
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.024
TI - Anticancer activity of novel 3-azaxanthenes
T2 - Mendeleev Communications
AU - Kibardina, Ludmila Konstantinovna
AU - Trifonov, Alexey Vladimirovich
AU - Dobrynin, Alexey Borisovich
AU - Pudovik, Michael Arkad'evich
AU - Burilov, Alexander Romanovich
AU - Voloshina, Alexandra Dmitrievna
AU - Strelnik, Anna Georgievna
AU - Gazizov, Almir Sabirovich
PY - 2021
DA - 2021/09/08
PB - Mendeleev Communications
SP - 664-666
IS - 5
VL - 31
ER -
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@article{2021_Kibardina,
author = {Ludmila Konstantinovna Kibardina and Alexey Vladimirovich Trifonov and Alexey Borisovich Dobrynin and Michael Arkad'evich Pudovik and Alexander Romanovich Burilov and Alexandra Dmitrievna Voloshina and Anna Georgievna Strelnik and Almir Sabirovich Gazizov},
title = {Anticancer activity of novel 3-azaxanthenes},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.024},
number = {5},
pages = {664--666},
doi = {10.1016/j.mencom.2021.09.024}
}
MLA
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MLA Copy
Kibardina, Ludmila Konstantinovna, et al. “Anticancer activity of novel 3-azaxanthenes.” Mendeleev Communications, vol. 31, no. 5, Sep. 2021, pp. 664-666. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.024.

Keywords

3-c]pyridines
3-azaxanthenes
anticancer activity
chromeno[2
Cyclization
cytotoxicity
naphthol
pyridoxal

Abstract

Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel–Crafts reaction of pyridoxal/pyridoxal-5'-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives. The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentrations range, which makes this class of compounds interesting for further studies.

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