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Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups

Sofiya Andreevna Zakharenkova 1
Sofiya Andreevna Zakharenkova
, 
Victoria Vadimovna Abzianidze 1
Victoria Vadimovna Abzianidze
, 
Natalia Ivanovna Moiseeva 2
Natalia Ivanovna Moiseeva
, 
Diana Sergeevna Lukina 1
Diana Sergeevna Lukina
, 
Leonid Sergeevich Chistyi 1
Leonid Sergeevich Chistyi
, 
Denis Victorovich Krivorotov 1
Denis Victorovich Krivorotov
, 
Yury Georgievich Trishin 3
Yury Georgievich Trishin
10.1016/j.mencom.2021.09.023
Published 2021-09-08
Communication , Volume 31, Issue 5, 662-663
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Zakharenkova S. A. et al. Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 662-663.
GOST all authors (up to 50) Copy
Zakharenkova S. A., Abzianidze V. V., Moiseeva N. I., Lukina D. S., Chistyi L. S., Krivorotov D. V., Trishin Y. G. Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 662-663.
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TY - JOUR
DO - 10.1016/j.mencom.2021.09.023
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.023
TI - Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups
T2 - Mendeleev Communications
AU - Zakharenkova, Sofiya Andreevna
AU - Abzianidze, Victoria Vadimovna
AU - Moiseeva, Natalia Ivanovna
AU - Lukina, Diana Sergeevna
AU - Chistyi, Leonid Sergeevich
AU - Krivorotov, Denis Victorovich
AU - Trishin, Yury Georgievich
PY - 2021
DA - 2021/09/08
PB - Mendeleev Communications
SP - 662-663
IS - 5
VL - 31
ER -
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@article{2021_Zakharenkova,
author = {Sofiya Andreevna Zakharenkova and Victoria Vadimovna Abzianidze and Natalia Ivanovna Moiseeva and Diana Sergeevna Lukina and Leonid Sergeevich Chistyi and Denis Victorovich Krivorotov and Yury Georgievich Trishin},
title = {Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Sep},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.023},
number = {5},
pages = {662--663},
doi = {10.1016/j.mencom.2021.09.023}
}
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Zakharenkova, Sofiya Andreevna, et al. “Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups.” Mendeleev Communications, vol. 31, no. 5, Sep. 2021, pp. 662-663. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.09.023.

Keywords

in vitro studies
anticancer agents
antitumor activity
etoposide
N-heterocyclic compounds
natural products
phaeosphaeride A
sulfides

Abstract

New C(6)-derivatives of natural phaeosphaeride A (PPA) modified with pharmacophoric nitrogen heterocyclic groups have been synthesized. The reaction of 1,2,4-triazole with PPA mesylate produced both the product of the expected substitution of the methanesulfonate group and the PPA derivative with two 1,2,4-triazole groups: at the C(6) atom and the exocyclic C=C bond. The synthesized compounds, with the exception of those containing two 1,2,4-triazole groups, are superior in cytotoxic activity to the original phaeosphaeride and the positive control, etoposide.

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