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Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin

Ekaterina Vladimirovna Kuznetsova 1
Ekaterina Vladimirovna Kuznetsova
, 
Kirill Timurovich Kalinin 1
Kirill Timurovich Kalinin
, 
Nikita Gennad'evich Sedush 1
Nikita Gennad'evich Sedush
, 
Alexey Anatol'evich Nazarov 2
Alexey Anatol'evich Nazarov
,  , 
Sergei Nikolaevich Chvalun 1, 3
Sergei Nikolaevich Chvalun
10.1016/j.mencom.2021.07.025
Published 2021-07-07
Communication , Volume 31, Issue 4, 512-514
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Kuznetsova E. V. et al. Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 512-514.
GOST all authors (up to 50) Copy
Kuznetsova E. V., Kalinin K. T., Sedush N. G., Nazarov A. A., Volkov D. S., Chvalun S. N. Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin // Mendeleev Communications. 2021. Vol. 31. No. 4. pp. 512-514.
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TY - JOUR
DO - 10.1016/j.mencom.2021.07.025
UR - https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.025
TI - Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin
T2 - Mendeleev Communications
AU - Kuznetsova, Ekaterina Vladimirovna
AU - Kalinin, Kirill Timurovich
AU - Sedush, Nikita Gennad'evich
AU - Nazarov, Alexey Anatol'evich
AU - Volkov, Dmitry Sergeyevich
AU - Chvalun, Sergei Nikolaevich
PY - 2021
DA - 2021/07/07
PB - Mendeleev Communications
SP - 512-514
IS - 4
VL - 31
ER -
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@article{2021_Kuznetsova,
author = {Ekaterina Vladimirovna Kuznetsova and Kirill Timurovich Kalinin and Nikita Gennad'evich Sedush and Alexey Anatol'evich Nazarov and Dmitry Sergeyevich Volkov and Sergei Nikolaevich Chvalun},
title = {Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Mendeleev Communications},
month = {Jul},
url = {https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.025},
number = {4},
pages = {512--514},
doi = {10.1016/j.mencom.2021.07.025}
}
MLA
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Kuznetsova, Ekaterina Vladimirovna, et al. “Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin.” Mendeleev Communications, vol. 31, no. 4, Jul. 2021, pp. 512-514. https://mendcomm.colab.ws/publications/10.1016/j.mencom.2021.07.025.

Abstract

Spherical nanoparticles based on the biocompatible and biodegradable poly(d,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.

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